Reviewed on 6/6/2022

What Is Xylometazoline and How Does It Work?

Xylometazoline is an over-the-counter (OTC) medication used for treating nasal congestion.

  • Xylometazoline is available under the following different brand names: Triaminic Decongestant Spray Nasal & Sinus Congestion

What Are Dosages of Xylometazoline?

Adult and pediatric dosage

Nasal drops/spray

  • 0.05%

Nasal Congestion

Adult dosage

  • Aged below 12 years: Not recommended
  • Aged above 12 years: 0.05% Spray (2-3 drops/sprays) per nostril every 8-10 hours; no more than 3 doses/day

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Are Side Effects Associated with Using Xylometazoline?

Common side effects of the Xylometazoline include:

  • temporary burning, 
  • stinging, 
  • dryness in the nose, 
  • runny nose, and 
  • sneezing.

Serious side effects of the Xylometazoline include:

  • slow/fast/pounding heartbeat,
  • dizziness,
  • nausea,
  • headache, 
  • mental/mood changes,
  • trouble sleeping, 
  • shaking (tremors), 
  • unusual sweating,
  • unusual weakness
  • rash,
  • itching/swelling (especially of the face/tongue/throat), 
  • severe dizziness, 
  • trouble breathing.

Rare side effects of the Xylometazoline include:

  • none 

This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

What Other Drugs Interact with Xylometazoline?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Xylometazoline has severe interactions with the following drugs:
  • Xylometazoline has serious interactions with at least 25 other drugs.
  • Xylometazoline has moderate interactions with at least 168 other drugs.
  • Xylometazoline has minor interactions with the following drugs:

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Xylometazoline?


Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Xylometazoline?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Xylometazoline?”


  • None

Pregnancy and Lactation

  • Use with caution if benefits outweigh risks during pregnancy
  • Lactation
    • Not known if excreted in breast milk

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