- Same Thing
- Side Effects
- What Is
- Drug Interactions
Are Xywav and Provigil the Same Thing?
Xywav (calcium, magnesium, potassium, and sodium oxybates) and Provigil (modafinil) are used to treat excessive daytime sleepiness (EDS) in patients with narcolepsy.
Xywav is also used to treat cataplexy in patients with narcolepsy.
Provigil is also used to increase wakefulness in patients with excessive sleepiness related shiftwork sleep disorder and obstructive sleep apnea/hypopnea syndrome.
Xywav and Provigil belong to different drug classes. Xywav is a central nervous system depressant and Provigil is a stimulant.
Side effects of Xywav and Provigil that are similar include headache, nausea, dizziness, diarrhea, and anxiety.
Side effects of Xywav that are different from Provigil include decreased appetite, abnormal sleep behaviors (parasomnia), increased sweating, vomiting, bed wetting (in children), and weight loss.
Side effects of Provigil that are different from Xywav include upper respiratory tract infection, nervousness, agitation, dry mouth, and trouble sleeping (insomnia).
Xywav may interact with divalproex sodium, alcohol, sedative hypnotics, and other central nervous system (CNS) depressants.
Provigil may interact with cyclosporine, theophylline, hormonal contraceptives, warfarin, diazepam, propranolol, imipramine, desipramine, phenytoin, carbamazepine, rifampin, ketoconazole, and itraconazole.
You could have unpleasant withdrawal symptoms if you change the dose or stop using Xywav suddenly.
What Are Possible Side Effects of Xywav?
Side effects of Xywav include:
- decreased appetite,
- abnormal sleep behaviors (parasomnia),
- increased sweating,
- bed wetting (in children), and
- weight loss
What Are Possible Side Effects of Provigil?
Common side effects of Provigil include:
- upper respiratory tract infection,
- dry mouth, and
- trouble sleeping (insomnia).
Tell your doctor if you experience serious side effects of Provigil including:
- easy bruising or bleeding,
- chest pain,
- fast/pounding/irregular heartbeat, or
- mental/mood changes (such as confusion, depression, hallucinations, rare thoughts of suicide).
What Is Xywav?
Xywav (calcium, magnesium, potassium, and sodium oxybates) is a central nervous system depressant indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy.
What Is Provigil?
Provigil (modafinil) is a stimulant prescribed to increase wakefulness in patients with excessive sleepiness related to narcolepsy, shiftwork sleep disorder, and obstructive sleep apnea/hypopnea syndrome.
What Drugs Interact With Xywav?
Xywav may interact with other medicines such as:
- divalproex sodium,
- sedative hypnotics, and
- other central nervous system (CNS) depressants
Tell your doctor all medications and supplements you use.
What Drugs Interact With Provigil?
Provigil drug interactions include cyclosporine (Sandimmune), theophylline (Theo-24), hormonal contraceptives (for example, Micronor), warfarin (Coumadin), diazepam (Valium), propranolol (Inderal), imipramine (Tofranil), desipramine (Norpramin), phenytoin (Dilantin), carbamazepine (Tegretol), rifampin (Rifadin), Ketoconazole (Nizoral) and itraconazole (Sporanox). Provigil has not been adequately studied in pregnant women and it is unknown if it is excreted in breast milk. Consult your doctor before breastfeeding.
How Should Xywav be Taken?
The adult starting dose of Xywav is 4.5 g per night orally, divided into two doses. Titrate to effect in increments of up to 1.5 g per night per week. The recommended dosage range of Xywav for adults is 6 g to 9 g per night orally. The recommended pediatric starting dosage, titration regimen, and maximum total nightly dosage of Xywav are based on body weight.
How Should Provigil be Taken?
Provigil dosage is 200 or 400 mg daily.
Health Solutions From Our Sponsors
All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).
Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.
Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.
The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.
As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.
Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.
If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.
You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.
FDA. Provigil Product Information.