Xywav vs. Provigil

Reviewed on 4/20/2021

Are Xywav and Provigil the Same Thing?

Xywav (calcium, magnesium, potassium, and sodium oxybates) and Provigil (modafinil) are used to treat excessive daytime sleepiness (EDS) in patients with narcolepsy.

Xywav is also used to treat cataplexy in patients with narcolepsy.

Provigil is also used to increase wakefulness in patients with excessive sleepiness related shiftwork sleep disorder and obstructive sleep apnea/hypopnea syndrome.

Xywav and Provigil belong to different drug classes. Xywav is a central nervous system depressant and Provigil is a stimulant.

Side effects of Xywav and Provigil that are similar include headache, nausea, dizziness, diarrhea, and anxiety.

Side effects of Xywav that are different from Provigil include decreased appetite, abnormal sleep behaviors (parasomnia), increased sweating, vomiting, bed wetting (in children), and weight loss.

Side effects of Provigil that are different from Xywav include upper respiratory tract infection, nervousness, agitation, dry mouth, and trouble sleeping (insomnia).

Xywav may interact with divalproex sodium, alcohol, sedative hypnotics, and other central nervous system (CNS) depressants.

Provigil may interact with cyclosporine, theophylline, hormonal contraceptives, warfarin, diazepam, propranolol, imipramine, desipramine, phenytoin, carbamazepine, rifampin, ketoconazole, and itraconazole.

You could have unpleasant withdrawal symptoms if you change the dose or stop using Xywav suddenly.

What Are Possible Side Effects of Xywav?

Side effects of Xywav include:

  • headache,
  • nausea,
  • dizziness,
  • decreased appetite,
  • abnormal sleep behaviors (parasomnia),
  • diarrhea,
  • increased sweating,
  • anxiety,
  • vomiting,
  • bed wetting (in children), and
  • weight loss

What Are Possible Side Effects of Provigil?

Common side effects of Provigil include:

  • headache,
  • dizziness,
  • upper respiratory tract infection,
  • nausea,
  • diarrhea,
  • nervousness,
  • anxiety,
  • agitation,
  • dry mouth, and
  • trouble sleeping (insomnia).

Tell your doctor if you experience serious side effects of Provigil including:

  • fever,
  • easy bruising or bleeding,
  • hallucinations,
  • depression,
  • chest pain,
  • fast/pounding/irregular heartbeat, or
  • mental/mood changes (such as confusion, depression, hallucinations, rare thoughts of suicide).

QUESTION

Why do we sleep? See Answer

What Is Xywav?

Xywav (calcium, magnesium, potassium, and sodium oxybates) is a central nervous system depressant indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy.

What Is Provigil?

Provigil (modafinil) is a stimulant prescribed to increase wakefulness in patients with excessive sleepiness related to narcolepsy, shiftwork sleep disorder, and obstructive sleep apnea/hypopnea syndrome.

What Drugs Interact With Xywav?

Xywav may interact with other medicines such as:

  • divalproex sodium,
  • alcohol,
  • sedative hypnotics, and
  • other central nervous system (CNS) depressants

Tell your doctor all medications and supplements you use.

What Drugs Interact With Provigil?

Provigil drug interactions include cyclosporine (Sandimmune), theophylline (Theo-24), hormonal contraceptives (for example, Micronor), warfarin (Coumadin), diazepam (Valium), propranolol (Inderal), imipramine (Tofranil), desipramine (Norpramin), phenytoin (Dilantin), carbamazepine (Tegretol), rifampin (Rifadin), Ketoconazole (Nizoral) and itraconazole (Sporanox). Provigil has not been adequately studied in pregnant women and it is unknown if it is excreted in breast milk. Consult your doctor before breastfeeding.

How Should Xywav be Taken?

The adult starting dose of Xywav is 4.5 g per night orally, divided into two doses. Titrate to effect in increments of up to 1.5 g per night per week. The recommended dosage range of Xywav for adults is 6 g to 9 g per night orally. The recommended pediatric starting dosage, titration regimen, and maximum total nightly dosage of Xywav are based on body weight.

How Should Provigil be Taken?

Provigil dosage is 200 or 400 mg daily.

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References
Jazz Pharmaceuticals. Xywav Product Information.

https://www.xywav.com/

FDA. Provigil Product Information.

https://www.fda.gov/media/79539/download

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