Xywav vs. Sunosi

Reviewed on 4/20/2021

Are Xywav and Sunosi the Same Thing?

Xywav (calcium, magnesium, potassium, and sodium oxybates) and Sunosi (solriamfetol) are used to treat excessive daytime sleepiness (EDS) in patients with narcolepsy.

Xywav is also used to treat cataplexy in patients with narcolepsy.

Sunosi is also used to improve wakefulness in adult patients with excessive daytime sleepiness associated with obstructive sleep apnea (OSA).

Xywav and Sunosi belong to different drug classes. Xywav is a central nervous system depressant and Sunosi is a dopamine and norepinephrine reuptake inhibitor (DNRI).

Side effects of Xywav and Sunosi that are similar include headache, nausea, decreased appetite, and anxiety.

Side effects of Xywav that are different from Sunosi include dizziness, abnormal sleep behaviors (parasomnia), diarrhea, increased sweating, vomiting, bed wetting (in children), and weight loss.

Side effects of Sunosi that are different from Xywav include insomnia.

Xywav may interact with divalproex sodium, alcohol, sedative hypnotics, and other central nervous system (CNS) depressants.

Sunosi may interact with monoamine oxidase inhibitors (MAOIs), other drugs that increase blood pressure and/or heart rate, and dopaminergic drugs.

You could have unpleasant withdrawal symptoms if you change the dose or stop using Xywav suddenly.

What Are Possible Side Effects of Xywav?

Side effects of Xywav include:

  • headache,
  • nausea,
  • dizziness,
  • decreased appetite,
  • abnormal sleep behaviors (parasomnia),
  • diarrhea,
  • increased sweating,
  • anxiety,
  • vomiting,
  • bed wetting (in children), and
  • weight loss

What Are Possible Side Effects of Sunosi?

Common side effects of Sunosi include:

  • headache,
  • nausea,
  • decreased appetite,
  • insomnia, and
  • anxiety

QUESTION

Why do we sleep? See Answer

What Is Xywav?

Xywav (calcium, magnesium, potassium, and sodium oxybates) is a central nervous system depressant indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy.

What Is Sunosi?

Sunosi (solriamfetol) is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated to improve wakefulness in adult patients with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea (OSA).

What Drugs Interact With Xywav?

Xywav may interact with other medicines such as:

  • divalproex sodium,
  • alcohol,
  • sedative hypnotics, and
  • other central nervous system (CNS) depressants

Tell your doctor all medications and supplements you use.

What Drugs Interact With Sunosi?

Sunosi may interact with monoamine oxidase inhibitors (MAOIs), other drugs that increase blood pressure and/or heart rate, and dopaminergic drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Sunosi; it is unknown how it would affect a fetus. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Sunosi during pregnancy. It is unknown if Sunosi passes into breast milk. Consult your doctor before breastfeeding.

How Should Xywav be Taken?

The adult starting dose of Xywav is 4.5 g per night orally, divided into two doses. Titrate to effect in increments of up to 1.5 g per night per week. The recommended dosage range of Xywav for adults is 6 g to 9 g per night orally. The recommended pediatric starting dosage, titration regimen, and maximum total nightly dosage of Xywav are based on body weight.

How Should Sunosi be Taken?

Sunosi is administered once daily upon awakening. The starting dose of Sunosi for patients with narcolepsy is 75 mg once daily. The starting dose of Sunosi for patients with OSA is 37.5 mg once daily.

SLIDESHOW

Sleep Disorders: Foods That Help Sleep or Keep You Awake See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

Health Solutions From Our Sponsors