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Xyzal vs. Clarinex

Reviewed on 7/9/2019

Are Xyzal and Clarinex the Same Thing?

Xyzal (levocetirizine dihydrochloride) and Clarinex (desloratadine) are antihistamines indicated for the relief of symptoms associated with allergies, such as sneezing, watery eyes, and runny nose.

Clarinex is also used to treat skin hives and itching in people with chronic skin reactions.

Xyzal and Clarinex are available over-the-counter (OTC).

Side effects of Xyzal and Clarinex that are similar include drowsiness, fatigue, tired feeling, sore throat, cough, diarrhea, and dry mouth.

Side effects of Xyzal that are different from Clarinex include weakness, stuffy nose, sinus pain, vomiting, constipation, and weight gain.

Side effects of Clarinex that are different from Xyzal include muscle pain, nausea, indigestion, loss of appetite, dizziness, headache, trouble sleeping, nosebleeds, stomach upset, and fever.

Xyzal may interact with alcohol, other medicines that can make you drowsy (cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, and medicines for seizures, depression, or anxiety), ritonavir, and theophylline.

Clarinex may interact with other drugs.

What Are Possible Side Effects of Xyzal?

Common side effects of Xyzal include:

  • drowsiness,
  • fatigue,
  • weakness,
  • tired feeling,
  • stuffy nose,
  • sinus pain,
  • sore throat,
  • cough,
  • vomiting,
  • diarrhea,
  • constipation,
  • dry mouth, or
  • weight gain

Tell your doctor if you have serious side effecs of Xyzal including:

  • lightheadedness,
  • nosebleeds (especially in a child),
  • pain or fullness in your ear,
  • hearing problems,
  • depression,
  • agitation,
  • aggression,
  • hallucinations,
  • numbness or tingling around your lips or mouth,
  • yellowing of your skin or eyes (jaundice),
  • painful or difficult urination,
  • dark-colored urine,
  • foul-smelling stools,
  • fever,
  • stomach pain, or
  • loss of appetite

What Are Possible Side Effects of Clarinex?

Common side effects of Clarinex include:

  • sore throat,
  • muscle pain,
  • nausea,
  • indigestion,
  • loss of appetite,
  • diarrhea,
  • drowsiness,
  • tired feeling,
  • dizziness,
  • fatigue,
  • headache,
  • trouble sleeping,
  • nosebleeds,
  • cough,
  • stomach upset,
  • fever, or
  • dry mouth.

A very serious allergic reaction to Clarinex is rare. Get medical help right away if you notice symptoms of a serious allergic reaction, including:

  • rash,
  • itching/swelling (especially of the face/tongue/throat),
  • severe dizziness, or
  • trouble breathing.

What Is Xyzal?

Xyzal (levocetirizine dihydrochloride) is an antihistamine indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 2 years of age and older.

What is Clarinex?

Clarinex (desloratadine) is an antihistamine used to treat the symptoms of allergies, such as sneezing, watery eyes, and runny nose. Clarinex is also used to treat skin hives and itching in people with chronic skin reactions. Clarinex is available over-the-counter and in generic form.


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow

What Drugs Interact With Xyzal?

Xyzal may interact with alcohol, other medicines that can make you drowsy (cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, medicine for seizures, depression or anxiety). Xyzal may also interact with ritonavir or theophylline.

What Drugs Interact With Clarinex?

There may be other drugs that can affect Clarinex. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Clarinex should be used only when prescribed during pregnancy. This drug passes into breast milk. Consult your doctor before breastfeeding.

How Should Xyzal Be Taken?

Xyzal is available as 2.5 mg/5 mL (0.5 mg/mL) oral solution and as 5 mg breakable (scored) tablets, allowing for the administration of 2.5 mg, if needed. Xyzal can be taken without regard to food consumption.

How Should Clarinex Be Taken?

The recommended dose of Clarinex for adults and children 12 years or older is 5 mg daily. Syrup can be used for children two years and older with the dose dependent on the age of the child.


Allergies can best be described as: See Answer

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Merck. Clarinex Product Information.

Sanofi. Xyzal Product Information.

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