Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 12/15/2021
Drug Description

What is Yocon and how is it used?

Yocon is a prescription medicine used to treat the symptoms of Impotence or Erectile Dysfunction. Yocon may be used alone or with other medications.

Yocon belongs to a class of drugs called Urology, Herbals.

It is not known if Yocon is safe and effective in children.

What are the possible side effects of Yocon?

Yocon may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • mental or mood changes,
  • anxiety,
  • irritability,
  • nervousness,
  • shaking or tremor,
  • change in the amount of urine,
  • rash, and
  • severe dizziness

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Yocon include:

  • headache,
  • dizziness,
  • nausea, and
  • flushing

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Yocon. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Yohimbine is a 3alpha -15alpha -20beta -17alpha -hydroxy Yohimbine-16alpha - carboxylic acid methyl ester. The alkaloid is found in Rubaceae and related trees. Also in Rauwolfia Serpentina (L) Benth. Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine. It is a crystalline powder, odorless. Each compressed tablet contains (1/12 gr.) 5.4 mg of Yohimbine Hydrochloride.

Indications & Dosage


Yocon (yohimbine hydrochloride) is indicated as a sympathicolytic and mydriatic. It may have activity as an aphrodisiac.


Experimental dosage reported in treatment of erectile impotence:1, 3, 4 1 tablet (5.4 mg) 3 times a day, to adult males taken orally. Occasional side effects reported with this dosage are nausea, dizziness or nervousness. In the event of side effects dosage is to be reduced to ½ tablet 3 times a day, followed by gradual increases to 1 tablet 3 times a day. Reported therapy not more than 10 weeks.3


Yocon ® (Yohimbine Hydrochloride, USP) Tablets 1/12 gr 5.4 mg Bottles of 100 - NDC 0516-0001-01 Bottles of 1,000 - NDC 0516-0001-10

 1. A. Morales et al., New England Journal of Medicine: 1221. November 12, 1981.

 3. Weekly Urological Clinical letter, 27:2, July 4, 1983

 4. A. Morales et al., The Journal of Urology 128: 45-47, 1982.

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Erectile Dysfunction (ED) Causes and Treatment See Slideshow
Side Effects & Drug Interactions


Yohimbine readily penetrates the CNS and produces a complex pattern of responses in lower doses than required to produce peripheral alpha-adrenergic blockade. These include, anti-diuresis, a general picture of central excitation including elevation of blood pressure and heart rate, increased motor activity, irritability, and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug.1,2 Also dizziness, headache, skin flushing reported when used orally.1,3


No information provided.

 1. A. Morales et al., New England Journal of Medicine: 1221. November 12, 1981.

 2. Goodman, Gilman - The Pharmacological basis of Therapeutics 6th ed., p. 176- 188, McMillan

 3. Weekly Urological Clinical letter, 27:2, July 4, 1983

Warnings & Precautions


Generally, this drug is not proposed for use in females and certainly must not be used during pregnancy. Neither is this drug proposed for use in pediatric, geriatric or cardio-renal patients with gastric or duodenal ulcer history. Nor, should it be used in conjunction with mood-modifying drugs such as antidepressants, or in psychiatric patients in general.


No information provided.

Overdosage & Contraindications


No information provided.


Renal diseases, and patients sensitive to the drug. In view of the limited and inadequate information at hand, no precise tabulation can be offered of additional contraindications.

Clinical Pharmacology



Yocon (yohimbine hydrochloride) blocks presynaptic alpha-2 adrenergic receptors. Its action on peripheral blood vessels resembles that of reserpine, though it is weaker and of shorter duration. Yohimbine's peripheral autonomic nervous system effect is to increase parasympathetic (cholinergic) and decrease sympathetic (adrenergic) activity. It is to be noted that in male sexual performance, erection is linked to cholinergic activity and to alpha-2 adrenergic blockade which may theoretically result in increased penile inflow, decreased penile outflow or both.

Yohimbine exerts a stimulating action on the mood and may increase anxiety. Such actions have not been adequately studied or related to dosage although they appear to require high doses of the drug. Yohimbine has a mild anti-diuretic action, probably via stimulation of hypothalamic centers and release of posterior pituitary hormone.

Reportedly, Yohimbine exerts no significant influence on cardiac stimulation and other effects mediated by beta-adrenergic receptors. Its effect on blood pressure, if any, would be to lower it; however, no adequate studies are at hand to quantitate this effect in terms of Yohimbine dosage.

Medication Guide


No information provided. Please refer to the WARNINGS section.

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