What Is Yohimbine and How Does It Work?

Yohimbine is a sympatholytic and mydriatic drug used to treat impotence in male patients with vascular or diabetic origins and psychogenic origins.

Yohimbine is available under the following different brand names: Aphrodyne, and Yocon.

Dosages of Yohimbine:

Dosage Forms and Strengths


  • 5.4 mg

Dosage Considerations – Should be Given as Follows:

Impotence, aphrodisiac

  • 0.5-1 tablet/caplet three times daily
  • Pediatric: Safety and efficacy not established

What Are Side Effects Associated with Using Yohimbine?

Common side effects of Yohimbine include:

  • Anxiety
  • Irritability
  • Headache
  • Sweating
  • Nausea
  • Fast heart rate
  • Prolonged or painful erection (priapism)
  • Worsening of panic attacks
  • Vomiting
  • Dizziness
  • Nervousness
  • Restlessness
  • Reduced urination
  • Elevated blood pressure
  • Tremors
  • Skin flushing

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Yohimbine?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe interactions of yohimbine include:

Yohimbine has serious interactions with at least 30 different drugs.

Yohimbine has moderate interactions with at least 168 different drugs.

Mild interactions of yohimbine include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

What Are Warnings and Precautions for Yohimbine?


This medication contains yohimbine. Do not take Aphrodyne or Yocon if you are allergic to yohimbine or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Yohimbine?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Yohimbine?"


  • None

Pregnancy and Lactation

  • No information is available about use of yohimbine during pregnancy. Consult your doctor.
  • It is not known if yohimbine is excreted in breast milk. No information is available about use of yohimbine while breastfeeding. Consult your doctor.
Medscape. Yohimbine.
RxList. Yohimbine.

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