Yuvafem vs. Premarin

Reviewed on 2/2/2021

Are Yuvafem and Premarin the Same Thing?

Yuvafem (estradiol tablet) and Premarin (conjugated estrogens) are forms of the female hormone estrogen used to treat atrophic vaginitis due to menopause.

Premarin is also used to treat symptoms of menopause such as hot flashes. Premarin is also used to prevent osteoporosis in postmenopausal women, and replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Conjugated estrogens such as Premarin are sometimes used as part of cancer treatment in women and men.

Side effects of Yuvafem and Premarin that are similar include vaginal itching, headache, and abdominal pain/stomach upset or cramps.

Side effects of Yuvafem that are different from Premarin include back pain, diarrhea, vaginal yeast infection, and upper respiratory tract infection.

Side effects of Premarin that are different from Yuvafem include nausea, vomiting, bloating, breast tenderness or swelling, weight or appetite changes, freckles or darkening of facial skin, increased hair growth, loss of scalp hair, problems with contact lenses, vaginal discharge, changes in menstrual periods, decreased sex drive, nervousness, dizziness, and tired feeling.

Both Yuvafem and Premarin may interact with seizure medicines, barbiturates, rifampin, ketoconazole, and itraconazole.

Yuvafem may also interact with St. John's wort, erythromycin, clarithromycin, ritonavir, and grapefruit juice.

Premarin may also interact with blood thinners, thyroid medications, insulin or oral diabetes medicines, and antidepressants.

What Are Possible Side Effects of Yuvafem?

What Are Side Effects of Yuvafem?

Side effects of Yuvafem include:

What Are Possible Side Effects of Premarin?

Common side effects of Premarin Vaginal Cream include:

  • nausea,
  • vomiting,
  • bloating,
  • stomach cramps,
  • breast pain/tenderness/swelling,
  • headache,
  • weight changes,
  • changes in appetite,
  • freckles or darkening of facial skin,
  • increased hair growth,
  • loss of scalp hair,
  • problems with contact lenses,
  • vaginal itching or discharge,
  • changes in your menstrual periods,
  • decreased sex drive,
  • nervousness,
  • dizziness, or
  • tired feeling.


What Is Osteoporosis? Treatment, Symptoms, Medication See Slideshow

What Is Yuvafem?

Yuvafem (estradiol tablet) is a form of the female hormone estrogen used to treat atrophic vaginitis due to menopause.

What Is Premarin?

Premarin Vaginal Cream (conjugated estrogens) is a mixture of estrogen hormones, a female sex hormone produced by the ovaries, used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

What Drugs Interact With Yuvafem?

Yuvafem may interact with other medicines such as:

  • St. John's wort,
  • phenobarbital,
  • carbamazepine,
  • rifampin,
  • erythromycin,
  • clarithromycin,
  • ketoconazole,
  • itraconazole,
  • ritonavir, and
  • grapefruit juice

Tell your doctor all medications and supplements you use.

What Drugs Interact With Premarin?

Premarin Vaginal Cream may interact with blood thinners, thyroid medications, insulin or diabetes medicine taken by mouth, rifampin, ketoconazole or itraconazole, seizure medicines, barbiturates, or antidepressants. Tell your doctor all medications you are taking.

How Should Yuvafem be Taken?

Yuvafem should be administered intravaginally using the supplied applicator: 1 insert daily for 2 weeks, followed by 1 insert twice weekly (for example, Tuesday and Friday). Generally, women should be started at the 10 mcg dosage strength.

How Should Premarin be Taken?

Premarin Vaginal Cream is administered intravaginally in a cyclic regimen (daily for 21 days and then off for 7 days). The usual starting dosage strength is 0.5 g. Adjustments may be made based on individual response.


If menopause occurs in a woman younger than ___ years, it is considered to be premature. See Answer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

Amneal. Yuvafem Product Information.


Pfizer. Premarin Prescribing Information.


Health Solutions From Our Sponsors