Zamicet

Last updated on RxList: 7/24/2018
Zamicet Side Effects Center

Last reviewed on RxList 7/24/2018

Zamicet (hydrocodone bitartrate and acetaminophen oral solution) is a combination of a narcotic pain reliever and cough suppressant, and a non-narcotic pain reliever, used to relieve moderate to moderately severe pain. Common side effects of Zamicet include:

  • abdominal pain
  • constipation
  • difficulty urinating
  • dizziness
  • drowsiness
  • fear
  • fuzzy thinking
  • general feeling of discomfort or illness
  • lightheadedness
  • mood changes
  • nausea
  • nervousness
  • rash
  • shortness of breath
  • slower reactions
  • unusual tiredness, and
  • vomiting
The usual adult dosage of Zamicet is one tablespoonful (15 mL) every four to six hours as needed for pain. The total daily dosage of Zamicet should not exceed 6 tablespoons. Zamicet may interact with alcohol and other CNS depressants, other narcotics, other products that contain acetaminophen, antihistamines, antipsychotics, antianxiety agents, MAO inhibitors, or tricyclic antidepressants. Tell your doctor all medications and supplements you use. During pregnancy, Zamicet should be used only if prescribed. Babies born to mothers who have used narcotics such as those in Zamicet may have withdrawl symptoms such as irritability and excessive crying, tremors, hyperactive reflexes, increased respiratory rate, increased stools, sneezing, yawning, vomiting, and fever. Acetaminophen passes into breast milk but its effects on a nursing infant are unknown. It is unknown if hydrocodone passes into breast milk. Breastfeeding while taking Zamicet is not recommended. Withdrawal symptoms may occur if you suddenly stop taking Zamicet.

Our Zamicet (hydrocodone bitartrate and acetaminophen oral solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Medically speaking, the term "myalgia" refers to what type of pain? See Answer
Zamicet Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Call your doctor at once if you have:

  • noisy breathing, sighing, shallow breathing, breathing that stops;
  • a light-headed feeling, like you might pass out;
  • liver problems--nausea, upper stomach pain, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • low cortisol levels-- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; o
  • high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.

Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.

Common side effects include:

  • dizziness, drowsiness, feeling tired;
  • nausea, vomiting, stomach pain;
  • constipation; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Zamicet (Hydrocodone Bitartrate and Acetaminophen Oral Solution)

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Zamicet Professional Information

SIDE EFFECTS

Potential effects of high dosage are also listed in the OVERDOSAGE section.

Cardio-renal: Bradycardia, cardiac arrest, circulatory collapse, renal toxicity, renal tubular necrosis, hypotension.

Central Nervous System/Psychiatric: Anxiety, dizziness, drowsiness, dysphoria, euphoria, fear, general malaise, impairment of mental and physical performance, lethargy, light-headedness, mental clouding, mood changes, psychological dependence, sedation, somnolence progressing to stupor or coma.

Endocrine: Hypoglycemic coma.

Gastrointestinal System: Abdominal pain, constipation, gastric distress, heartburn, hepatic necrosis, hepatitis, occult blood loss, nausea, peptic ulcer, and vomiting.

Genitourinary System: Spasm of vesical sphincters, ureteral spasm, and urinary retention.

Hematologic: Agranulocytosis, hemolytic anemia, iron deficiency anemia, prolonged bleeding time, thrombocytopenia.

Hypersensitivity: Allergic reactions.

Musculoskeletal: Skeletal muscle flaccidity.

Respiratory Depression: Acute airway obstruction, apnea, dose-related respiratory depression (see OVERDOSAGE), shortness of breath.

Special Senses: Cases of hearing impairment or permanent loss have been reported predominantly in patients with chronic overdose.

Skin: Cold and clammy skin, diaphoresis, pruritus, rash.

Drug Abuse And Dependence

Misuse, Abuse And Diversion Of Opioids

Zamicet® contains hydrocodone, an opioid agonist, and is a Schedule II controlled substance. Zamicet®, and other opioids used in analgesia can be abused and are subject to criminal diversion.

Addiction is a primary, chronic, neurobiologic disease, with genetic, psychosocial, and environmental factors influencing its development and manifestations. It is characterized by behaviors that include one or more of the following: impaired control over drug use, compulsive use, continued use despite harm, and craving. Drug addiction is a treatable disease utilizing a multidisciplinary approach, but relapse is common.

“Drug seeking” behavior is very common in addicts and drug abusers. Drug-seeking tactics include emergency calls or visits near the end of office hours, refusal to undergo appropriate examination, testing or referral, repeated “loss” of prescriptions, tampering with prescriptions and reluctance to provide prior medical records or contact information for other treating physician(s). “Doctor shopping” to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction.

Abuse and addiction are separate and distinct from physical dependence and tolerance. Physical dependence usually assumes clinically significant dimensions only after several weeks of continued opioid use, although a mild degree of physical dependence may develop after a few days of opioid therapy. Tolerance, in which increasingly large doses are required in order to produce the same degree of analgesia, is manifested initially by a shortened duration of analgesic effect, and subsequently by decreases in the intensity of analgesia. The rate of development of tolerance varies among patients. Physicians should be aware that abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances. Hydrocodone bitartrate and acetaminophen, like other opioids, may be diverted for non-medical use. Record-keeping of prescribing information, including quantity, frequency, and renewal requests is strongly advised.

Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs.

Read the entire FDA prescribing information for Zamicet (Hydrocodone Bitartrate and Acetaminophen Oral Solution)

© Zamicet Patient Information is supplied by Cerner Multum, Inc. and Zamicet Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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