Zegerid vs. Protonix

Are Zegerid and Protonix the Same Thing?

Zegerid (omeprazole/sodium bicarbonate) and Protonix Delayed-Release Oral Suspension and Delayed-Release Tablets (pantoprazole sodium) are used to treat gastroesophageal reflux disease (GERD).

Zegerid is also used to treat ulcers and other conditions involving excessive stomach acid production.

Protonix is used for short-term treatment (less than 10 days) of gastroesophageal reflux disease (GERD) and a history of erosive esophagitis in adult patients.

Both Zegerid and Protonix contain a proton-pump inhibitor (PPI). Zegerid also contains an antacid.

Side effects of Zegerid and Protonix that are similar include headache, stomach or abdominal pain, nausea, gas, and diarrhea.

Side effects of Protonix that are different from Zegerid include injection site reactions (redness, pain, swelling), vomiting, dizziness, joint pain, weight changes, drowsiness, tired feeling, and sleep problems (insomnia).

Both Zegerid and Protonix may interact with blood thinners, methotrexate, iron supplements (including ferrous fumarate, ferrous gluconate, ferrous sulfonate), diuretics (water pills), digoxin, HIV/AIDS medicines, antibiotics, and antifungals.

Zegerid may also interact with bosentan, citalopram, clopidogrel, cyclosporine, diazepam or similar sedatives, digitalis, disulfiram, antabuse, rifabutin, rifampin, rifapentine, sodium polystyrene sulfonate, St. John's wort, tacrolimus, calcium supplements, and seizure medications.

What Are Possible Side Effects of Zegerid?

Common side effects of Zegerid include:

    • headache stomach or abdominal pain,
    • nausea,
    • gas, or
    • diarrhea.

    Tell your doctor if you have unlikely but serious side effects of Zegerid including:

    • swelling of the hands or feet,
    • symptoms of a low magnesium blood level (such as unusually fast/slow/irregular heartbeat, persistent muscle spasms, seizures), or
    • sudden weight gain.

    What Are Possible Side Effects of Protonix?

    Common side effects of Protonix include:

    • injection site reactions (redness, pain, swelling),
    • headache,
    • nausea,
    • vomiting,
    • abdominal or stomach pain,
    • diarrhea,
    • gas,
    • dizziness,
    • joint pain,
    • weight changes,
    • drowsiness,
    • tired feeling, or
    • sleep problems (insomnia).

    What is Zegerid?

    Zegerid (omeprazole/sodium bicarbonate) is a combination of a proton-pump inhibitor (PPI) and an antacid used to treat ulcers, gastroesophageal reflux disease (GERD), and other conditions involving excessive stomach acid production. Zegerid may be available in generic form.

    What is Protonix?

    Protonix IV (pantoprazole sodium) is a proton pump inhibitor (PPI) used for short-term treatment (less than 10 days) of gastroesophageal reflux disease (GERD) and a history of erosive esophagitis in adult patients.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow

What Drugs Interact With Zegerid?

Zegerid may interact with bosentan, citalopram, clopidogrel, cyclosporine, diazepam or similar sedatives, digoxin, digitalis, disulfiram, Antabuse, methotrexate, rifabutin, rifampin, rifapentine, sodium polystyrene sulfonate, St. John's wort, tacrolimus, antibiotics, antifungals, blood thinners, calcium supplements or iron supplements (including ferrous fumarate, ferrous gluconate, ferrous sulfonate), diuretics (water pills), HIV medicines, or seizure medications. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Zegerid; it is unknown if Zegerid will harm a fetus. Zegerid can pass into breast milk and may harm a nursing baby. Breastfeeding while using Zegerid is not recommended.

What Drugs Interact With Protonix?

Drug interactions include Valium (diazepam), Nizoral (ketoconazole), Lanoxin (digoxin), Invirase (saquinavir), Viracept (nelfinavir), Reyataz (atazanavir), Plavix (clopidogrel), and Pletal (cilostazol). Protonix should be used during pregnancy only if clearly needed.

How Should Zegerid Be Taken?

Dose and duration of treatment with Zegerid depends on the condition being treated. For ulcers, GERD, erosive esophagitis and eradication of H. pylori the usual recommended dose for adults is 20-40 mg daily. Follow instructions from your doctor.

How Should Protonix Be Taken?

The recommended adult dose of Protonix is 40 mg once daily.

  • Protonix Oral Suspension should be taken 30 minutes before a meal
  • Protonix Oral Suspension should only be taken with applesauce or apple juice 30 minutes before a meal.
  • Protonix Oral Suspension should not be taken in or with water or other liquids, or with other foods.
  • Protonix Oral Suspension should not be chewed or crushed.
  • Protonix Oral Suspension packet should not be divided to make a smaller dose.
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Bayer. Zegerid Product Information

https://www.zegeridotc.com

FDA. Protonix Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020987s045lbl.pdf

Health Solutions From Our Sponsors