Zegerid vs. Zantac

Are Zegerid and Zantac the Same Thing?

Zegerid (omeprazole/sodium bicarbonate) and Zantac (ranitidine hydrochloride) are used to treat ulcers.

Zegerid is also used to treat gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid production.

Zantac is also used to treat heartburn, erosive esophagitis, and Zollinger Ellison syndrome.

Zegerid and Zantac belong to different drug classes. Zegerid is a combination of a proton-pump inhibitor (PPI) and an antacid and Zantac is an H2 (histamine-2) receptor blocker.

Side effects of Zegerid and Zantac that are similar include headache, stomach or abdominal pain, nausea, and diarrhea.

Side effects of Zegerid that are different from Zantac include gas.

Side effects of Zantac that are different from Zegerid include constipation, diarrhea, fatigue, drowsiness, dizziness, sleep problems (insomnia), decreased sex drive, impotence, difficulty having an orgasm, muscle pain, vomiting, constipation, and swollen or tender breasts (in men).

Both Zegerid and Zantac may interact with blood thinners, antifungals, and HIV medicines.

Zegerid may also interact with bosentan, citalopram, clopidogrel, cyclosporine, diazepam or similar sedatives, digoxin, digitalis, disulfiram, Antabuse, methotrexate, rifabutin, rifampin, rifapentine, sodium polystyrene sulfonate, St. John's wort, tacrolimus, antibiotics, calcium supplements or iron supplements (including ferrous fumarate, ferrous gluconate, ferrous sulfonate), diuretics (water pills), and seizure medications.

Zantac may also interact with triazolam, procainamide, riazolam, midazolam, glipizide, delavirdine, and gefitinib.

What Are Possible Side Effects of Zegerid?

Common side effects of Zegerid include:

  • headache stomach or abdominal pain,
  • nausea,
  • gas, or
  • diarrhea.

Tell your doctor if you have unlikely but serious side effects of Zegerid including:

  • swelling of the hands or feet,
  • symptoms of a low magnesium blood level (such as unusually fast/slow/irregular heartbeat, persistent muscle spasms, seizures), or
  • sudden weight gain.

What Are Possible Side Effects of Zantac?

Common side effects of Zantac include:

  • constipation,
  • diarrhea,
  • fatigue,
  • headache (may be severe),
  • drowsiness,
  • dizziness,
  • sleep problems (insomnia),
  • decreased sex drive,
  • impotence,
  • difficulty having an orgasm,
  • muscle pain,
  • stomach pain,
  • nausea,
  • vomiting,
  • diarrhea,
  • constipation,
  • or swollen or tender breasts (in men).

What is Zegerid?

Zegerid (omeprazole/sodium bicarbonate) is a combination of a proton-pump inhibitor (PPI) and an antacid used to treat ulcers, gastroesophageal reflux disease (GERD), and other conditions involving excessive stomach acid production. Zegerid may be available in generic form.

What is Zantac?

Zantac (ranitidine hydrochloride) is a H2 (histamine-2) receptor blocker used for treating and preventing ulcers in the duodenum and stomach. Zantac is also used for treating:

  • heartburn,
  • erosive esophagitis,
  • and Zollinger Ellison syndrome.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow

What Drugs Interact With Zegerid?

Zegerid may interact with bosentan, citalopram, clopidogrel, cyclosporine, diazepam or similar sedatives, digoxin, digitalis, disulfiram, Antabuse, methotrexate, rifabutin, rifampin, rifapentine, sodium polystyrene sulfonate, St. John's wort, tacrolimus, antibiotics, antifungals, blood thinners, calcium supplements or iron supplements (including ferrous fumarate, ferrous gluconate, ferrous sulfonate), diuretics (water pills), HIV medicines, or seizure medications. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Zegerid; it is unknown if Zegerid will harm a fetus. Zegerid can pass into breast milk and may harm a nursing baby. Breastfeeding while using Zegerid is not recommended.

What Drugs Interact With Zantac?

Zantac may interact with ketoconazole, atazanavir, and blood thinners such as warfarin.

Zantac may also interact with triazolam, procainamide, riazolam, midazolam, glipizide, delavirdine, and gefitinib.

How Should Zegerid Be Taken?

Dose and duration of treatment with Zegerid depends on the condition being treated. For ulcers, GERD, erosive esophagitis and eradication of H. pylori the usual recommended dose for adults is 20-40 mg daily. Follow instructions from your doctor.

How Should Zantac Be Taken?

Zantac is available in tablet, syrup, and injectable formulations.

  • adults and children 12 years and over:
    • to relieve symptoms, swallow 1 tablet with a glass of water
    • to prevent symptoms, swallow 1 tablet with a glass of water 30 to 60 minutes before eating food or drinking beverages that cause heartburn
    • can be used up to twice daily (do not take more than 2 tablets in 24 hours)
  • children under 12 years: ask a doctor

Other Information

  • do not use if printed foil under bottle cap is open or torn (bottles)
  • do not use if individual blister unit is open or torn (blisters)
  • do not use if individual foil packet is open or torn (pouch)
  • store at 20°-25°C (68°-77°F)
  • avoid excessive heat or humidity
  • this product is sodium and sugar free
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References
Bayer. Zegerid Product Information

https://www.zegeridotc.com

Sanofi. Zantac Product Information.

https://www.zantacotc.com

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