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Last reviewed on RxList: 9/7/2018
Zenzedi Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 9/7/2018

Zenzedi (dextroamphetamine sulfate tablets) is an amphetamine for the treatment of narcolepsy. Zenzedi is also indicated as a treatment for attention deficit hyperactivity disorder (ADHD) in pediatric patients ages 3 to 16 years as an integral part of a total treatment program for ADHD that may include counseling or other therapies. Common side effects of Zenzedi include:

  • seizures,
  • blurred vision,
  • dry mouth,
  • rapid heart beat,
  • tremors,
  • decreased appetite,
  • trouble sleeping (insomnia),
  • stomach upset,
  • headache,
  • weight loss,
  • dizziness,
  • heart palpitations,
  • elevated blood pressure,
  • overstimulation,
  • restlessness,
  • euphoria,
  • anxiety,
  • involuntary movements,
  • unpleasant taste in mouth,
  • diarrhea,
  • constipation,
  • hives,
  • impotence, and
  • changes in sex drive.

The usual dose of Zenzedi to treat narcolepsy is 5 to 60 mg per day in divided doses, depending on the individual patient response. The initial dose of Zenzedi to treat ADHD in pediatric patients 3 to 5 years of age is 2.5 mg daily, by tablet. In pediatric patients 6 years of age and older, the starting dose of Zenzedi is 5 mg once or twice daily. Zenzedi may interact with guanethidine, reserpine, glutamic acid HCl, ascorbic acid, fruit juices, ammonium chloride, sodium acid phosphate, adrenergic blockers, alkalinizing agents, tricyclic antidepressants, MAO inhibitors, antihistamines, antihypertensives, chlorpromazine, ethosuximide, haloperidol, lithium carbonate, meperidine, methenamine therapy, norepinephrine, phenobarbital, phenytoin, propoxyphene, and veratrum alkaloids. Tell your doctor all medications and supplements you use. Zenzedi should only be used during pregnancy if prescribed; it is unknown how it might affect a fetus. Zenzedi passes into breast milk. Breastfeeding is not recommended while taking Zenzedi. Withdrawal symptoms may occur if you suddenly stop taking Zenzedi.

Our Zenzedi (dextroamphetamine sulfate tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


ADHD Symptoms in Children See Slideshow
Zenzedi Professional Information



Palpitations, tachycardia, elevation of blood pressure. There have been isolated reports of cardiomyopathy associated with chronic amphetamine use.

Central Nervous System

Psychotic episodes at recommended doses (rare), overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics and Tourette's syndrome.


Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances. Anorexia and weight loss may occur as undesirable effects.




Impotence, changes in libido, frequent or prolonged erections.



Drug Abuse And Dependence

Zenzedi is a Schedule II controlled substance.

Amphetamines have been extensively abused. Tolerance, extreme psychological dependence and severe social disability have occurred. There are reports of patients who have increased the dosage to many times that recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG.

Manifestations of chronic intoxication with amphetamines include severe dermatoses, marked insomnia, irritability, hyperactivity and personality changes. The most severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia. This is rare with oral amphetamines.

Read the entire FDA prescribing information for Zenzedi (Dextroamphetamine Sulfate Tablets, USP)


The abbreviated term ADHD denotes the condition commonly known as: See Answer
Related Resources for Zenzedi

© Zenzedi Patient Information is supplied by Cerner Multum, Inc. and Zenzedi Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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