Are Zinbryta and Gilenya the Same Thing?
Because of its safety profile, the use of Zinbryta should generally be reserved for patients who have had an inadequate response to two or more drugs indicated for the treatment of MS.
Zinbryta and Gilenya belong to different drug classes. Zinbryta is an interleukin-2 receptor blocking antibody and Gilenya is a sphingosine 1-phosphate receptor modulator.
Side effects of Zinbryta and Gilenya that are similar include influenza and increased liver transaminases.
Side effects of Zinbryta that are different from Gilenya include runny or stuffy nose, upper respiratory tract infection, bronchitis, skin rash (including drug rash), mouth pain, sore throat, eczema, swollen lymph nodes, depression, anemia, acne, and fever.
Zinbryta may interact with drugs or herbal products that are toxic to the liver.
Gilenya may interact with beta-blockers, calcium channel blockers, citalopram, chlorpromazine, digoxin, erythromycin, haloperidol, ketoconazole, medications to control the immune system, medications for cancer, heart or blood pressure medicines, and methadone.
What Are Possible Side Effects of Zinbryta?
Common side effects of Zinbryta include:
- runny or stuffy nose
- upper respiratory tract infection
- rash, including drug rash
- skin rash
- mouth pain
- sore throat
- swollen lymph nodes
- increased alanine aminotransferase (ALT)
- anemia, and
Less common side effects of Zinbryta include:
- abnormal liver function test,
- decreased lymphocyte count
- dry skin
- skin redness
- hair bumps (folliculitis)
- increased liver enzymes
- enlarged lymph nodes
- skin peeling
- toxic skin eruption, and
- viral infection
What Are Possible Side Effects of Gilenya?
Common side effects of Gilenya include:
- tired feeling,
- stuffy nose,
- sinus pain,
- back pain,
- liver transaminase elevations, and
Gilenya can affect your immune system's ability to fight an infection while you are taking the medication and for 2 months after your last dose. Tell your doctor right away if you develop signs of an infection such as:
- persistent cough or sore throat,
- difficulty breathing,
- chills, or
- cold/flu symptoms.
What Is Zinbryta?
Zinbryta (daclizumab) injection is an interleukin-2 receptor blocking antibody indicated for the treatment of adult patients with relapsing forms of multiple sclerosis (MS). Because of its safety profile, the use of Zinbryta should generally be reserved for patients who have had an inadequate response to two or more drugs indicated for the treatment of MS.
What Is Gilenya?
Gilenya (fingolimod) is a sphingosine 1-phosphate receptor modulator used to treat patients with relapsing forms of multiple sclerosis (MS) to reduce the frequency of exacerbations and to delay physical disability.
What Drugs Interact With Zinbryta?
Zinbryta may interact with hepatotoxic drugs or herbal products. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant before taking Zinbryta. It is unknown if it would affect a fetus. It is unknown if Zinbryta passes into breast milk or if it would affect a nursing infant. Consult your doctor before breastfeeding.
What Drugs Interact With Gilenya?
Gilenya may interact with beta-blockers, calcium channel blockers, citalopram, chlorpromazine, digoxin, erythromycin, haloperidol, ketoconazole, medications to control the immune system, medications for cancer, heart problems, or high blood pressure, and methadone. Tell your doctor all medications and supplements you use. Gilenya may cause fetal harm. It takes approximately 2 months for Gilenya to be eliminated from the body. Women should avoid pregnancy during treatment with Gilenya and for 2 months after treatment. It is not known if Gilenya passes into breast milk. Women and their doctors should decide whether to take Gilenya or breastfeed. Women should not do both.
All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).
Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.
Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.
The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.
As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.
Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.
If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.
You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.
Novartis. Gilenya Product Information