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Zinecard

Last reviewed on RxList: 1/21/2021
Zinecard Side Effects Center

What Is Zinecard?

Zinecard (dexrazoxane) is a cardioprotective agent that is used to protect the heart from harmful side effects caused by doxorubicin used in women who are receiving doxorubicin for metastatic breast cancer. Zinecard is available in generic form.

What Are Side Effects of Zinecard?

Common side effects of Zinecard include nausea, vomiting, loss of appetite, trouble swallowing, diarrhea, temporary hair loss, swelling in your hands or feet, sore throat, dizziness, tired feeling, or injection site reactions (pain, irritation, swelling, or redness). Because Zinecard is used with another medication, it may be difficult to tell which side effects it causes.

Dosage for Zinecard

The dose of Zinecard depends on the dose of doxorubicin. The recommended dosage ratio of Zinecard:doxorubicin is 10:1 (e.g., 500 mg/m² Zinecard:50 mg/m² doxorubicin).

What Drugs, Substances, or Supplements Interact with Zinecard?

Zinecard may interact with fluorouracil, or cyclophosphamide. Tell your doctor all medications and supplements you use.

Zinecard During Pregnancy and Breastfeeding

During pregnancy, Zinecard should be used only when prescribed. This drug passes into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Additional Information

Our Zinecard (dexrazoxane) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Zinecard Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fever, chills, tiredness, mouth sores, skin sores;
  • easy bruising, unusual bleeding;
  • sore throat, cough, trouble breathing; or
  • bruising, swelling, warmth, redness, oozing, or bleeding of any surgical incision.

Common side effects may include:

  • nausea, vomiting;
  • fever;
  • infection after a surgery; or
  • pain where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Zinecard (Dexrazoxane)

Zinecard Professional Information

SIDE EFFECTS

ZINECARD at a dose of 500 mg/m² has been administered in combination with FAC in randomized, placebo-controlled, double-blind studies to patients with metastatic breast cancer. The dose of doxorubicin was 50 mg/m² in each of the trials. Courses were repeated every three weeks, provided recovery from toxicity had occurred. Table 3 below lists the incidence of adverse experiences for patients receiving FAC with either ZINECARD or placebo in the breast cancer studies. Adverse experiences occurring during courses 1 through 6 are displayed for patients receiving ZINECARD or placebo with FAC beginning with their first course of therapy (columns 1 and 3, respectively).  Adverse experiences occurring at course 7 and beyond for patients who received placebo with FAC during the first six courses and who then received either ZINECARD or placebo with FAC are also displayed (columns 2 and 4, respectively).

Table 3

EXPERIENCE FAC + ZINECARD FAC + PLACEBO
Courses 1-6
N =413
Courses ≥ 7
N = 102
Courses 1-6
N =458
Course ≥ 7
N = 99
Alopecia 94 100 97 98
Nausea 77 51 84 60
Vomiting 59 42 72 49
Fatigue/Malaise 61 48 58 55
Anorexia 42 27 47 38
Stomatitis 34 26 41 28
Fever 34 22 29 18
Infection 23 19 18 21
Diarrhea 21 14 24 7
Pain on injection 12 13 3 0
Sepsis 17 12 14 9
Neurotoxicity 17 10 13 5
Streaking/ Erythema 5 4 4 2
Phlebitis 6 3 3 5
Esophagitis 6 3 7 4
Dysphagia 8 0 10 5
Hemorrhage 2 3 2 1
Extravasation 1 3 1 2
Urticaria 2 2 2 0
Recall Skin Reaction 1 1 2 0

The adverse experiences listed above are likely attributable to the FAC regimen with the exception of pain on injection that was observed mainly on the ZINECARD arm.

Myelosuppression

Patients receiving FAC with ZINECARD experienced more severe leukopenia, granulocytopenia, and thrombocytopenia at nadir than patients receiving FAC without ZINECARD, but recovery counts were similar for the two groups of patients.

Hepatic and Renal

Some patients receiving FAC + ZINECARD or FAC + placebo experienced marked abnormalities in hepatic or renal function tests, but the frequency and severity of abnormalities in bilirubin, alkaline phosphatase, BUN, and creatinine were similar for patients receiving FAC with or without ZINECARD.

Read the entire FDA prescribing information for Zinecard (Dexrazoxane)

Related Resources for Zinecard

© Zinecard Patient Information is supplied by Cerner Multum, Inc. and Zinecard Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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