Zinplava vs. Vancomycin

Are Zinplava and Vancomycin the Same Thing?

Zinplava (bezlotoxumab) and Vancocin (vancomycin) are used to treat Clostridium difficile infection (CDI).

Vancocin is also used to treat serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci also known as MRSA. Vancomycin is indicated for penicillin-allergic patients, for patients who cannot receive or who have failed to respond to other drugs, including the penicillins or cephalosporins, and for infections caused by vancomycin-susceptible organisms that are resistant to other antimicrobial drugs.

Zinplava and Vancocin belong to different drug classes. Zinplava is a human monoclonal antibody and Vancocin is an antibiotic.

Side effects of Zinplava that are different from Vancocin include nausea, fever, and headache.

Side effects of Vancocin that are different from Zinplava include serious allergic reactions (anaphylactoid reactions) including low blood pressure, wheezing, indigestion, hives, and itching. Rapid infusion of Vancocin may also cause flushing of the upper body (called "red neck" or "red man syndrome"), dizziness, low blood pressure, and pain and muscle spasm of the chest and back.

Zinplava may interact with other drugs.

Vancocin may interact with anesthetic agents and other potentially neurotoxic and/or nephrotoxic drugs (such as amphotericin B, aminoglycosides, bacitracin, polymyxin B, colistin, viomycin, and cisplatin).

What Are Possible Side Effects of Zinplava?

Common side effects of Zinplava include:

  • nausea,
  • fever, and
  • headache.

What Are Possible Side Effects of Vancomycin?

Common side effects of Vancomycin include:

  • serious allergic reactions (anaphylactoid reactions),
  • including low blood pressure,
  • wheezing,
  • indigestion,
  • hives, or
  • itching.
  • Rapid infusion of Vancomycin may also cause flushing of the upper body (called "red neck" or "red man syndrome"),
  • dizziness,
  • low blood pressure, or
  • pain and muscle spasm of the chest and back.

What Is Zinplava?

Zinplava (bezlotoxumab) injection is a human monoclonal antibody that binds to Clostridium difficile (C. Diff.) toxin B, indicated to reduce recurrence of Clostridium difficile infection (CDI) in patients 18 years of age or older who are receiving antibacterial drug treatment of CDI and are at a high risk for CDI recurrence.

What Is Vancomycin?

Vancomycin is an antibiotic indicated for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci. Vancomycin is indicated for penicillin-allergic patients, for patients who cannot receive or who have failed to respond to other drugs, including the penicillins or cephalosporins, and for infections caused by Vancomycin susceptible organisms that are resistant to other antimicrobial drugs.

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What Drugs Interact With Zinplava?

Zinplava may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Zinplava. It is unknown how it would affect a fetus. It is unknown if Zinplava passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Vancomycin?

Vancomycin may interact with blood thinners or seizure medications.

Vancomycin may also interact with cimetidine, lithium, or disulfiram.

How Should Zinplava Be Taken?

The recommended dose of Zinplava is a single dose of 10 mg/kg administered as an intravenous infusion over 60 minutes.

How Should Vancomycin Be Taken?

The usual daily intravenous adult dose of Vancomycin is 2 g divided either as 500 mg every 6 hours or 1 g every 12 hours. Vancomycin may interact with anesthetic agents, or other potentially neurotoxic and/or nephrotoxic drugs (such as amphotericin B, aminoglycosides, bacitracin, polymyxin B, colistin, viomycin, or cisplatin). Tell your doctor all medications and supplements you use. During pregnancy, this medication should be used only when prescribed. Vancomycin passes into breast milk. Consult your doctor before breastfeeding.

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References
Merck. Zinplava Drug Information.

https://www.merck.com/product/usa/pi_circulars/z/zinplava/zinplava_pi.pdf

Pfizer. Vancocin Prescribing Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/060180s047lbl.pdf

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