Last updated on RxList: 1/28/2021
Zioptan Side Effects Center

What Is Zioptan?

Zioptan (tafluprost ophthalmic solution) is a fluorinated analog of prostaglandin F2a indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

What Are Side Effects of Zioptan?

Common side effects of Zioptan include:

Other side effects of Zioptan include gradual changes in eyelashes and vellus hair ("peach fuzz" hairs) in the treated eye including darkening, increased length, changes in color, thickness, shape, and number of lashes. Eyelash changes are usually reversible upon discontinuation of treatment with Zioptan. Serious side effects include cataracts.

Dosage for Zioptan

Zioptan (tafluprost ophthalmic solution) is available in strength of 0.015 mg/mL in a solution. The recommended dose of Zioptan is one drop in the conjunctival sac of the affected eye(s) once daily in the evening. The dose should not exceed once daily.

What Drugs, Substances, or Supplements Interact with Zioptan?

Zioptan may interact with other drugs. Tell your doctor all medications and supplements you use.

Zioptan During Pregnancy and Breastfeeding

Zioptan should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. It is unknown if Zioptan passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Zioptan Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow
Zioptan Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using tafluprost ophthalmic and call your doctor at once if you have:

  • eye pain or redness;
  • itchy or watery eyes;
  • increased sensitivity to light; or
  • severe redness or burning of the eyes after using the drops.

Common side effects may include:

  • mild eye discomfort;
  • blurred vision; or
  • dry eyes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Zioptan (tafluprost)


What causes dry eyes? See Answer
Zioptan Professional Information


Clinical Studies Experience

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.

Preservative-containing or preservative-free tafluprost 0.0015% was evaluated in 905 patients in five controlled clinical studies of up to 24-months duration. The most common adverse reaction observed in patients treated with tafluprost was conjunctival hyperemia which was reported in a range of 4% to 20% of patients. Approximately 1% of patients discontinued therapy due to ocular adverse reactions.

Ocular adverse reactions reported at an incidence of ≥2% in these clinical studies included ocular stinging/irritation (7%), ocular pruritus including allergic conjunctivitis (5%), cataract (3%), dry eye (3%), ocular pain (3%), eyelash darkening (2%), growth of eyelashes (2%) and vision blurred (2%).

Nonocular adverse reactions reported at an incidence of 2% to 6% in these clinical studies in patients treated with tafluprost 0.0015% were headache (6%), common cold (4%), cough (3%) and urinary tract infection (2%).

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of tafluprost. Because postapproval adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Respiratory disorders: exacerbation of asthma, dyspnea

Eye disorders: iritis/uveitis

In postmarketing use with prostaglandin analogs, periorbital and lid changes including deepening of the eyelid sulcus have been observed.

Read the entire FDA prescribing information for Zioptan (tafluprost)

© Zioptan Patient Information is supplied by Cerner Multum, Inc. and Zioptan Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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