Zn-DTPA Side Effects Center

Last updated on RxList: 1/4/2023
Zn-DTPA Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Zn-DTPA?

Zn-DTPA (pentetate zinc trisodium) Injection is a chelating agent used to treat patients with known or suspected internal contamination with plutonium, americium, or curium to increase the rates of elimination.

What Are Side Effects of Zn-DTPA?

Zn-DTPA may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • cough, and
  • wheezing

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Zn-DTPA include:

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Zn-DTPA

The dose of Zn-DTPA for adults and adolescent is a single 1.0 gram initial dose administered intravenously. The pediatric dose (less than 12 years of age) is a single initial dose of 14 mg/kg administered intravenously not to exceed 1.0 gram.

What Drugs, Substances, or Supplements Interact with Zn-DTPA?

Zn-DTPA may interact with other drugs. Tell your doctor all medications and supplements you use.

Zn-DTPA During Pregnancy or Breastfeeding

During pregnancy, Zn-DTPA should be used only if prescribed. Radiocontaminants are known to pass into breast milk. Women with known or suspected internal contamination with radiocontaminants should not breastfeed, whether or not they are receiving chelation therapy. Precautions should be taken when discarding breast milk.

Additional Information

Our Zn-DTPA (pentetate zinc trisodium) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Zn-DTPA Professional Information


In the U.S. Registry, a total of 646 individuals received at least one dose of either Ca-DTPA or Zn-DTPA (pentetate zinc trisodium injection) . Of these, 62 received Zn-DTPA (pentetate zinc trisodium injection) by one or more routes of administration. Forty-eight individuals were dosed by intravenous administration, 18 by inhalation and 8 by other or unknown routes of administration.

Of the individuals that received Zn-DTPA (pentetate zinc trisodium injection) , 23/62 (37%) received one dose and 8 (13%) received two doses. The remaining 31 individuals received three or more doses. The largest number of Zn-DTPA (pentetate zinc trisodium injection) doses to a single individual was 574 doses delivered over 3.5 years.

Overall, the presence or absence of adverse events was recorded in 310/646 individuals. Of these 19 (6.1%) individuals reported at least one adverse event. The total number of recorded adverse events was 20. Of the 20 adverse events, 1 individual treated with Zn-DTPA (pentetate zinc trisodium injection) reported headache, lightheadedness, and pelvic pain.

Two individuals experienced cough and/or wheezing with nebulized Ca-DTPA therapy however there was no report of such events with nebulized Zn-DTPA (pentetate zinc trisodium injection) .

Read the entire FDA prescribing information for Zn-DTPA (Pentetate Zinc Trisodium Injection)


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© Zn-DTPA Patient Information is supplied by Cerner Multum, Inc. and Zn-DTPA Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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