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Zocor

Last reviewed on RxList: 1/17/2019
Zocor Patient Information Including Side Effects

Brand Names: Zocor

Generic Name: simvastatin

What is simvastatin (Zocor)?

Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides, and increase levels of "good" cholesterol (high-density lipoprotein, or HDL).

Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Simvastatin is used in adults and children who are at least 10 years old.

Simvastatin may also be used for purposes not listed in this medication guide.

What are the possible side effects of simvastatin (Zocor)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Also call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about simvastatin (Zocor)?

You should not take simvastatin if you are pregnant or breast-feeding, or if you have active liver disease.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Stop taking simvastatin and tell your doctor right away if you become pregnant.

Zocor Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking simvastatin (Zocor)?

You should not take simvastatin if you are allergic to it, or if:

  • you have active liver disease; or
  • you are pregnant or breast-feeding.

Some medicines can cause unwanted or dangerous effects when used with simvastatin. Your doctor may change your treatment plan if you also use medicine such as:

Tell your doctor if you have ever had:

  • liver disease;
  • kidney disease;
  • diabetes;
  • a thyroid disorder;
  • if you are of Asian descent; or
  • if you drink more than 2 alcoholic beverages daily.

Simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

Do not use simvastatin if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine. Stop taking simvastatin and tell your doctor right away if you become pregnant.

It is not safe to breast-feed a baby while you are using this medicine.

How should I take simvastatin (Zocor)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Simvastatin is usually taken in the evening or at bedtime.

Take simvastatin oral suspension (liquid) on an empty stomach.

Shake the liquid for at least 20 seconds before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

You may need to take simvastatin on a long-term basis. You may need to stop using simvastatin for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.

Simvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

You will need frequent medical tests.

Store at room temperature away from moisture, heat, and light.

Do not refrigerate or freeze the liquid medicine. Throw away any liquid that has not been used within 1 month after you first opened the bottle.

Zocor Patient Information including If I Miss a Dose

What happens if I miss a dose (Zocor)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (Zocor)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking simvastatin (Zocor)?

Grapefruit may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products.

Avoid eating foods high in fat or cholesterol, or simvastatin will not be as effective.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

What other drugs will affect simvastatin (Zocor)?

Tell your doctor about all your other medicines, especially:

This list is not complete and many other drugs may affect simvastatin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Zocor)?

Your pharmacist can provide more information about simvastatin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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