Zocor vs. Tricor, Trilipix

Are Zocor and Tricor, Trilipix the Same Thing?

Zocor (simvastatin) and Trilipix (fenofibric acid) lower lipids (fats) in the blood and are used to treat high cholesterol and high triglyceride levels.

Zocor is also used to treat heterozygous familial hypercholesterolemia (HeFH) in adolescents (males and females that are one-year post menarche, 10 to 17 years old).

Zocor and Trilipix belong to different drug classes. Zocor is an HMG-CoA reductase inhibitor (a “statin” drug) and Trilipix is a lipid regulating agent.

What Are Possible Side Effects of Zocor?

Common side effects of Zocor include:

  • heartburn,
  • gas,
  • bloating,
  • stomach pain,
  • indigestion,
  • nausea,
  • constipation,
  • diarrhea,
  • headache,
  • joint pain,
  • muscle pain,
  • skin rash,
  • sleep problems (insomnia),
  • mild memory problems or confusion, or
  • cold symptoms such as stuffy nose, sneezing, or sore throat.

What Are Possible Side Effects of Tricor, Trilipix?

Common side effects of Tricor, Trilipix include:

  • abdominal or stomach pain,
  • nausea,
  • vomiting,
  • back pain,
  • headache,
  • runny or stuffy nose,
  • yellowing eyes/skin,
  • dark urine,
  • rash,
  • itching, and
  • swelling.


How to Lower Your Cholesterol & Save Your Heart See Slideshow

What Is Zocor?

Zocor (simvastatin) is a statin that lowers lipids and cholesterol levels used in conjunction with lifestyle changes such as a low-fat, low cholesterol diet, and exercise to reduce the chances of cardiovascular disease and ischemic strokes in patients with elevated lipids and cholesterol. Zocor is also used to treat heterozygous familial hypercholesterolemia (HeFH) in adolescents (males and females that are one-year post menarche, 10 to 17 years old). Zocor is available in generic form.

What Is Tricor, Trilipix?

Tricor, Trilipix (fenofibrate) is an antilipemic agent and fibric acid prescribed for reducing "bad" cholesterol and fats (for example, LDL and triglycerides) and for raising "good" cholesterol (HDL) in the blood.

What Drugs Interact With Zocor?

Tell your doctor about all other medications you use. Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them:

Also tell your doctor if you use:

This list is not complete and other drugs may interact with lovastatin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

What Drugs Interact With Tricor, Trilipix?

Tricor, Trilipix may interact with blood thinners, medicines to treat a bowel disorder, medications to prevent organ transplant rejection, antiviral medications, chemotherapy, pain or arthritis medicines (including aspirin, acetaminophen, ibuprofen, and naproxen), or injected antibiotics. Tell your doctor all medications and supplements you use. There are no adequate studies of Tricor in pregnant women. Tricor passes into breast milk and may harm a nursing baby. Breastfeeding while taking Tricor is not recommended. Use during pregnancy is not recommended unless the potential benefit outweighs the potential unknown risk to the fetus.

How Should Zocor Be Taken?

The usual dosage range is 5 to 40 mg/day. In patients with CHD or at high risk of CHD, ZOCOR can be started simultaneously with diet. The recommended usual starting dose is 10 or 20 mg once a day in the evening. For patients at high risk for a CHD event due to existing CHD, diabetes, peripheral vessel disease, history of stroke or other cerebrovascular disease, the recommended starting dose is 40 mg/day. Lipid determinations should be performed after 4 weeks of therapy and periodically thereafter.

Restricted Dosing For 80 mg

Due to the increased risk of myopathy, including rhabdomyolysis, particularly during the first year of treatment, use of the 80-mg dose of ZOCOR should be restricted to patients who have been taking simvastatin 80 mg chronically (e.g., for 12 months or more) without evidence of muscle toxicity .

Patients who are currently tolerating the 80-mg dose of ZOCOR who need to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin should be switched to an alternative statin with less potential for the drug-drug interaction.

Due to the increased risk of myopathy, including rhabdomyolysis, associated with the 80-mg dose of ZOCOR, patients unable to achieve their LDL-C goal utilizing the 40-mg dose of ZOCOR should not be titrated to the 80-mg dose, but should be placed on alternative LDL-C-lowering treatment(s) that provides greater LDL-C lowering.

How Should Tricor, Trilipix Be Taken?

Tricor, Trlipix usual adult dose is 48-154 mg/day.


What is cholesterol? See Answer

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Merck. Zocor Product Information.

AbbVie Inc. Trilipix Prescribing Information.


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