Zofran vs. Aloxi

Are Zofran and Aloxi the Same Thing?

Zofran (ondansetron) and Aloxi (palonosetron hydrochloride) are antiemetics (anti-nausea and vomiting) prescribed to treat nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery.

What Are Possible Side Effects of Zofran?

Common side effects of Zofran include:

What Are Possible Side Effects of Aloxi?

Common side effects of Aloxi include:

  • headache,
  • constipation,
  • diarrhea,
  • dizziness, or
  • tired feeling.

Aloxi may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin. Get medical help right away if you develop the following symptoms while taking Aloxi:

  • fast heartbeat,
  • hallucinations,
  • loss of coordination,
  • severe dizziness,
  • severe nausea/vomiting/diarrhea,
  • twitching muscles,
  • unexplained fever, or
  • unusual agitation or restlessness.

What is Zofran?

Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Zofran is available in generic form.

What is Aloxi?

Aloxi (palonosetron hydrochloride) is an antiemetic and anti-nausea agent used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).


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What Drugs Interact With Zofran?

Zofran may interact with medicines to treat psychiatric disorders, narcotics, or seizure medications. Zofran may also interact with arsenic trioxide, tacrolimus, tramadol, antibiotics, antidepressants, anti-malaria medications, heart rhythm medicines, other medicines to prevent or treat nausea and vomiting, and migraine headache medicines.

What Drugs Interact With Aloxi?

Aloxi may interact with heart rhythm medicines. Aloxi may also interact with diuretics (water pills).

How Should Zofran Be Taken?

Zofran adult dose is 32-mg given as a single dose or divided in three 0.15-mg/kg divided doses infused over 15 minutes.

How Should Aloxi Be Taken?

Dosage of Aloxi for adults is a single 0.25 mg I.V. dose administered over 30 seconds, given approximately 30 minutes before the start of chemotherapy.


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Medical Editor: John P. Cunha, DO, FACOEP

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