Zofran vs. Aloxi

Are Zofran and Aloxi the Same Thing?

Zofran (ondansetron) and Aloxi (palonosetron hydrochloride) are antiemetics (anti-nausea and vomiting) prescribed to treat nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery.

What Are Possible Side Effects of Zofran?

Common side effects of Zofran include:

What Are Possible Side Effects of Aloxi?

Common side effects of Aloxi include:

  • headache,
  • constipation,
  • diarrhea,
  • dizziness, or
  • tired feeling.

Aloxi may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin. Get medical help right away if you develop the following symptoms while taking Aloxi:

  • fast heartbeat,
  • hallucinations,
  • loss of coordination,
  • severe dizziness,
  • severe nausea/vomiting/diarrhea,
  • twitching muscles,
  • unexplained fever, or
  • unusual agitation or restlessness.

What is Zofran?

Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Zofran is available in generic form.

What is Aloxi?

Aloxi (palonosetron hydrochloride) is an antiemetic and anti-nausea agent used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).

QUESTION

Pancreatitis is inflammation of an organ in the abdomen called the pancreas. See Answer

What Drugs Interact With Zofran?

Zofran may interact with medicines to treat psychiatric disorders, narcotics, or seizure medications. Zofran may also interact with arsenic trioxide, tacrolimus, tramadol, antibiotics, antidepressants, anti-malaria medications, heart rhythm medicines, other medicines to prevent or treat nausea and vomiting, and migraine headache medicines.

What Drugs Interact With Aloxi?

Aloxi may interact with heart rhythm medicines. Aloxi may also interact with diuretics (water pills).

How Should Zofran Be Taken?

Zofran adult dose is 32-mg given as a single dose or divided in three 0.15-mg/kg divided doses infused over 15 minutes.

How Should Aloxi Be Taken?

Dosage of Aloxi for adults is a single 0.25 mg I.V. dose administered over 30 seconds, given approximately 30 minutes before the start of chemotherapy.

SLIDESHOW

Super Tips to Boost Digestive Health: Bloating, Constipation, and More See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Medical Editor: John P. Cunha, DO, FACOEP

Health Solutions From Our Sponsors