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Zofran vs. Reglan

Are Zofran and Reglan the Same Thing?

Zofran (ondansetron) and Reglan (metoclopramide) are antiemetics (anti-nausea and vomiting) used to treat nausea and vomiting.

Zofran is often used to prevent and treat nausea and vomiting during chemotherapy and after surgery.

Reglan is also used to treat loss of appetite, heartburn and early satiety (feeling of fullness).

Zofran and Reglan belong to different antiemetic drug classes. Zofran is a selective 5-HT3 receptor antagonist and Reglan is a dopamine antagonist.

What Are Possible Side Effects of Zofran?

Common side effects of Zofran include:

What Are Possible Side Effects of Reglan?

Common side effects of Reglan include:

  • decreased energy,
  • tiredness,
  • diarrhea,
  • dizziness,
  • drowsiness,
  • headache,
  • nausea,
  • vomiting,
  • restlessness,
  • malaise,
  • trouble sleeping (insomnia),
  • breast tenderness or swelling,
  • changes in your menstrual periods, or
  • urinating more than usual.

Tell your doctor if you experience serious side effects of Reglan including:

  • tardive dyskinesia (unusual muscle movements),
  • muscle stiffness,
  • depression,
  • agitation, and
  • difficulty breathing.

What is Zofran?

Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Zofran is available in generic form.

What is Reglan?

Reglan (metoclopramide) is a dopamine antagonist that is used as an antiemetic (anti-vomiting) agent used to treat nausea, vomiting, loss of appetite, heartburn and early satiety (feeling of fullness). Reglan is available in generic form.

What Drugs Interact With Zofran?

Zofran may interact with medicines to treat psychiatric disorders, narcotics, or seizure medications. Zofran may also interact with arsenic trioxide, tacrolimus, tramadol, antibiotics, antidepressants, anti-malaria medications, heart rhythm medicines, other medicines to prevent or treat nausea and vomiting, and migraine headache medicines.

What Drugs Interact With Reglan?

Reglan may also interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), acetaminophen, cyclosporine, digoxin, glycopyrrolate, insulin, levodopa, mepenzolate, tetracycline, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bladder or urinary medications, blood pressure medications, bronchodilators, irritable bowel medications, or MAO inhibitors.

How Should Zofran Be Taken?

Zofran adult dose is 32-mg given as a single dose or divided in three 0.15-mg/kg divided doses infused over 15 minutes.

How Should Reglan Be Taken?

Reglan can be administered both orally and by IV or IM. IM doses range from 10-20 mg, while IV doses are usually only 10 mg. IV and IM doses are usually only given in hospitals or health care facilities. Oral doses can vary from 10 to 15 mg, and are taken four times per day to prevent vomiting and other symptoms.

Reviewed on 6/12/2018

Medical Editor: John P. Cunha, DO, FACOEP

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