Zoloft vs. Drizalma Sprinkle

Zoloft (sertraline) and Drizalma Sprinkle (duloxetine delayed-release capsules) are antidepressants used to treat depression.

Zoloft is also used to treat obsessive-compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

Drizalma Sprinkle is also used to treat generalized anxiety disorder in adults and pediatric patients ages 7 years to 17 years old, diabetic peripheral neuropathic pain in adults, and chronic musculoskeletal pain in adults.

Zoloft and Drizalma Sprinkle are different types of antidepressants. Drizalma Sprinkle is a serotonin and norepinephrine reuptake inhibitor (SNRI) and Zoloft is a selective serotonin reuptake inhibitor (SSRI).

Side effects of Drizalma Sprinkle and Zoloft that are similar include nausea, dry mouth, drowsiness, constipation, and changes in appetite.

Side effects of Drizalma Sprinkle that are different from Zoloft include increased sweating.

Side effects of Zoloft that are different from Drizalma Sprinkle include sleepiness, tired feeling, nervousness, sleep problems (insomnia), dizziness, skin rash, headache, diarrhea, upset stomach, stomach pain, abnormal ejaculation, impotence, decreased sex drive, difficulty having an orgasm, dry mouth, and weight loss.

Both Zoloft and Drizalma Sprinkle may interact with alcohol, other antidepressants, migraine headache medicines, fentanyl, lithium, tramadol, St. John's wort, cimetidine, nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners, and heart rhythm medications.

Zoloft may also interact with other medicines that make you sleepy (such as cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, and medicines for seizures or anxiety), digoxin, linezolid, 5-hydroxytryptophan, valproate, and cough and cold medicines.

Do not stop using Zoloft suddenly, or you could have unpleasant withdrawal symptoms.

Drizalma Sprinkle may also interact with monoamine oxidase inhibitors (MAOIs), tryptophan, buspirone, amphetamines, ciprofloxacin, enoxacin, aspirin, quinidine, phenothiazines, aluminum-and magnesium-containing antacids, famotidine, proton pump inhibitors (PPIs), theophylline, caffeine, centrally acting CNS drugs, and highly plasma protein binding drugs.

Common side effects of Zoloft include:

• sleepiness
• drowsiness
• tired feeling
• nervousness
• sleep problems (insomnia)
• dizziness
• nausea
• skin rash
• headache
• diarrhea
• constipation
• upset stomach
• stomach pain
• dry mouth
• changes in appetite
• abnormal ejaculation
• impotence
• decreased sex drive
• difficulty having an orgasm
• dry mouth, and
• weight loss.

Tell your doctor if you have serious side effects of Zoloft including:

• very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
• agitation, hallucinations, fever, overactive reflexes, tremors;
• nausea, vomiting, loss of appetite, feeling unsteady, loss of coordination;
• trouble concentrating, memory problems, weakness, fainting, seizure, shallow breathing, or breathing that stops.

Common side effects of Drizalma Sprinkle include:

• nausea,
• dry mouth,
• drowsiness,
• constipation,
• decreased appetite, and
• increased sweating

Zoloft is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD). Zoloft belongs to a class of medicines known as SSRIs.

Zoloft is also used to treat or manage:

• Major Depressive Disorder (MDD)
• Obsessive Compulsive Disorder (OCD)
• Panic Disorder
• Posttraumatic Stress Disorder (PTSD)
• Social Anxiety Disorder
• Premenstrual Dysphoric Disorder (PMDD)

It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it. You should discuss all treatment choices with your healthcare provider.

Zoloft is safe and effective in treating children with OCD age 6 to 17 years.

It is not known if Zoloft is safe and effective for use in children under 6 years of age with OCD or children with other behavior health conditions.

Talk to your healthcare provider if you do not think that your condition is getting better with Zoloft treatment.

Drizalma Sprinkle (duloxetine delayed-release capsules) is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for major depressive disorder in adults, generalized anxiety disorder in adults and pediatric patients ages 7 years to 17 years old, diabetic peripheral neuropathic pain in adults, and chronic musculoskeletal pain in adults.

Do Not take Zoloft if you:

• take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid.
• have taken an MAOI within 2 weeks of stopping Zoloft unless directed to do so by your healthcare provider.
• have stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider.
• take any other medicines that contain sertraline (such as sertraline HCl or sertraline hydrochloride).
• take the antipsychotic medicine pimozide (Orap^®) because this can cause serious heart problems.
• are allergic to sertraline or any of the ingredients in Zoloft. See the end of this Medication Guide for a complete list of ingredients in Zoloft.
• take Antabuse^® (disulfiram) (if you are taking the liquid form of Zoloft) due to the alcohol content.

People who take Zoloft close in time to an MAOI may have serious or even life-threatening side effects. Get medical help right away if you have any of these symptoms:

• high fever
• uncontrolled muscle spasms
• stiff muscles
• rapid changes in heart rate or blood
• confusion
• loss of consciousness (pass pressure out)

Drizalma Sprinkle may interact with monoamine oxidase inhibitors (MAOIs), triptans, tricyclic antidepressants, other SNRIs or SSRIs, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's wort, cimetidine, ciprofloxacin, enoxacin, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, warfarin, quinidine, phenothiazines, type 1C antiarrhythmics, aluminum-and magnesium-containing antacids, famotidine, proton pump inhibitors (PPIs), theophylline, caffeine, centrally acting CNS drugs, highly plasma protein binding drugs, and alcohol. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Drizalma Sprinkle; third trimester use may increase risk of symptoms of poor adaptation (respiratory distress, temperature instability, feeding difficulty, low muscle tone, tremor, irritability) in newborns. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antidepressants during pregnancy. Drizalma Sprinkle passes into breast milk but its effects on nursing infants are unknown. Consult your doctor before breastfeeding.

If you take too much Zoloft, call your healthcare provider or poison control center right away, or go to the nearest hospital emergency room right away.

The dose of Drizalma Sprinkle is 60 mg daily for most conditions.