Zovirax vs. Lysine

Are Zovirax and Lysine the Same Thing?

Zovirax (acyclovir) and lysine are used to treat different forms of herpes virus.

Zovirax is used to treat shingles, chickenpox, and genital herpes.

Lysine is used to treat cold sores (herpes simplex libialis). Lysine is also used for athletic performance enhancement, and to treat elevated pH (metabolic alkalosis).

Zovirax and lysine belong to different drug classes. Zovirax is a nucleoside analogue type antiviral and lysine is an herbal supplement.

Side effects of Zovirax and lysine that are similar include diarrhea and stomach/abdominal pain.

Side effects of Zovirax that are different from lysine include nausea, vomiting, loss of appetite, headache, lightheadedness, swelling in your hands and feet, and feeling unwell (malaise).

Side effects of lysine that are different from Zovirax include chronic kidney (renal) failure, inflammation in the kidney (interstitial nephritis), and increased calcium absorption.

Zovirax may interact with probenecid, other antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, injectable osteoporosis medication, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

Lysine may interact with other drugs.

What Are Possible Side Effects of Zovirax?

Common side effects of Zovirax include:

  • nausea,
  • vomiting,
  • diarrhea,
  • loss of appetite,
  • stomach pain,
  • headache,
  • lightheadedness,
  • swelling in your hands and feet,
  • and feeling unwell (malaise).

Serious side effects of Zovirax include renal function problem.

What Are Possible Side Effects of Lysine?

Common side effects of Lysine include:

  • diarrhea
  • abdominal pain
  • chronic kidney (renal) failure
  • inflammation in the kidney (interstitial nephritis)
  • increased calcium absorption

What is Zovirax?

Zovirax (acyclovir) is a synthetic nucleoside analogue that interferes with the replication of herpes viruses used to treat
  • shingles,
  • chickenpox,
  • and genital herpes.

What is Lysine?

Lysine is an herbal supplement used for athletic performance enhancement, or treatment for cold sores (herpes simplex libialis) and elevated pH (metabolic alkalosis).

Lysine is possibly effective for cold sores (herpes simplex labialis) treatment.

Lysine is available under the following different brand names: L-lysine and Lysine Monohydrochloride.

What Drugs Interact With Zovirax?

Zovirax may interact with probenecid. Tell your doctor all medications and supplements you use.

What Drugs Interact With Lysine?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Lysine has no known severe interactions with any drugs.

Lysine has no known serious interactions with any drugs.

Lysine has no known moderate interactions with any drugs.

Lysine has no known mild interaction with other drugs.

How Should Zovirax Be Taken?

Zovirax tablets are available in 200, 400 and 800 mg strengths and as a liquid suspension with 200 mg strength per 5 ml. Usual doses are 800 mg every 4 hours, 5 times a day for 10 days for shingles; doses for genital herpes infection are the same interval but start with 200 mg. Doses for chickenpox is the same as shingles except it goes for only 5 days for adults; for children ages 2 and up are weight based (20 mg per Kg) up to 40 Kg, 5 times a day for 5 days. Over 40 Kg, the person gets the adult dose for 5 days.

How Should Lysine Be Taken?

The dose of Lysine is as follows:

  • 1,000 mg orally daily for 12 months and
  • 1,000 mg orally three times daily 6 months

Topical: (Super Lysine Plus) applied every 2 hours for 11 days

Metabolic Alkalosis (elevated pH levels)

  • 10 grams orally once daily, divided doses for up to 5 days

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

GSK. Zovirax Drug Information.


Medscape. Lysine.


Health Solutions From Our Sponsors