ZTLido Side Effects Center

Last updated on RxList: 4/27/2022
ZTLido Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is ZTlido?

ZTlido (lidocaine topical system) is an amide local anesthetic indicated for relief of pain associated with post-herpetic neuralgia (PHN).

What Are Side Effects of ZTlido?

Common side effects of ZTlido include application site reactions that are mild and temporary such as

  • irritation,
  • redness,
  • itching,
  • blisters,
  • bruising,
  • burning sensation,
  • loss of skin pigmentation,
  • skin discoloration,
  • swelling,
  • exfoliation,
  • irritation,
  • bumps,
  • cysts, or
  • abnormal sensation

Dosage for ZTlido

Apply ZTlido to intact skin to cover the most painful area. Apply the prescribed number of topical systems (up to three) only once for up to 12 hours in a 24-hour period.

What Drugs, Substances, or Supplements Interact with ZTlido?

ZTlido may interact with antiarrhythmic drugs and other products containing local anesthetic agents. Tell your doctor all medications and supplements you use.

ZTlido During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using ZTlido it is unknown how it would affect a fetus. ZTlido passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our ZTlido (lidocaine topical system) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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ZTLido Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe burning, stinging, or irritation where the medicine was applied;
  • swelling or redness;
  • sudden dizziness or drowsiness after medicine is applied;
  • confusion, blurred vision, ringing in your ears; or
  • unusual sensations of temperature.

Common side effects include:

  • mild irritation where the medication is applied; or
  • numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for ZTLido (Lidocaine)


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ZTLido Professional Information


The following serious adverse reactions are described elsewhere in the labeling:

  • Excessive Dosing/Overexposure to Lidocaine [see WARNINGS AND PRECAUTIONS]
  • Methemoglobinemia [see WARNINGS AND PRECAUTIONS]
  • Application Site Reactions [see WARNINGS AND PRECAUTIONS]
  • Hypersensitivity Reactions [see WARNINGS AND PRECAUTIONS]
  • Eye Irritation [see WARNINGS AND PRECAUTIONS]

The following adverse reactions from voluntary reports or clinical studies have been reported with lidocaine. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Skin and subcutaneous tissues: blisters, bruising, burning sensation, depigmentation, dermatitis, discoloration, edema, erosions, erythema, exfoliation, flushing, irritation, papules, petechia, pruritus, vesicles, and abnormal sensation.

Immune system: angioedema, bronchospasm, dermatitis, dyspnea, hypersensitivity, laryngospasm, pruritus, shock, and urticaria.

Central Nervous System: lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, somnolence, respiratory depression and arrest.

Cardiovascular: bradycardia, hypotension, and cardiovascular collapse leading to arrest.

Other: asthenia, disorientation, headache, hyperesthesia, hypoesthesia, metallic taste, nausea, pain exacerbated, paresthesia, taste alteration, and vomiting.


Drugs That May Cause Methemoglobinemia When Used with ZTLIDO

Patients who are administered local anesthetics may be at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics:

Examples Of Drugs Associated With Methemoglobinemia

Class Examples
Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide
Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine
Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase
Antibiotics dapsone, nitrofurantoin, para-aminosalicyclic acid, sulfonamides
Antimalarials chloroquine, primaquine
Anticonvulsants phenobarbital, phenytoin, sodium valproate
Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine

Antiarrhythmic Drugs

When ZTLIDO is used in patients receiving Class I antiarrhythmic drugs (such as tocainide and mexiletine), the toxic effects are additive and potentially synergistic. Consider risk/benefit during concomitant use.

Local Anesthetics

When ZTLIDO is used concomitantly with other products containing local anesthetic agents, the effects are additive. Consider the amount of drug absorbed from all formulations when local anesthetic agents are administered concomitantly.

Read the entire FDA prescribing information for ZTLido (Lidocaine)

© ZTLido Patient Information is supplied by Cerner Multum, Inc. and ZTLido Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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