Zulresso vs. Zoloft

Reviewed on 9/23/2019

Are Zulresso and Zoloft the Same Thing?

Zulresso (brexanolone) Injection and Zoloft (sertraline) are antidepressants used to treat depression.

Zulresso is specifically used to treat postpartum depression (PPD) in adults. Zulresso is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the Zulresso REMS.

Zoloft is also used to treat obsessive-compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

Zulresso and Zoloft are different types of antidepressants. Zulresso is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor positive modulator and Zoloft is a selective serotonin reuptake inhibitor (SSRI).

Side effects of Zulresso and Zoloft that are similar include drowsiness, sleepiness, and dry mouth.

Side effects of Zulresso that are different from Zoloft include loss of consciousness, flushing, and hot flushes.

Side effects of Zoloft that are different from Zulresso include tired feeling, nervousness, sleep problems (insomnia), dizziness, nausea, skin rash, headache, diarrhea, constipation, upset stomach, stomach pain, changes in appetite, abnormal ejaculation, impotence, decreased sex drive, difficulty having an orgasm, dry mouth, and weight loss.

Both Zulresso and Zoloft may interact with other antidepressants and other medicines that make you sleepy (such as cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, and medicines for seizures or anxiety).

Zoloft may also interact with nonsteroidal anti-inflammatory drugs (NSAIDs), cimetidine, digoxin, fentanyl, linezolid, lithium, St. John's wort, tramadol, 5-hydroxytryptophan, valproate, blood thinners, cough and cold medicines, heart rhythm medications, or migraine headache medicines.

Do not stop using Zoloft suddenly, or you could have unpleasant withdrawal symptoms.

What Are Possible Side Effects of Zulresso?

Common side effects of Zulresso include:

  • nausea
  • diarrhea
  • dry mouth
  • constipation
  • vomiting
  • gas
  • dizziness
  • abnormal dreams
  • itching, and
  • decreased sexual desire

What Are Possible Side Effects of Zoloft?

Common side effects of Zoloft include:

  • sleepiness
  • drowsiness
  • tired feeling
  • nervousness
  • sleep problems (insomnia)
  • dizziness
  • nausea
  • skin rash
  • headache
  • diarrhea
  • constipation
  • upset stomach
  • stomach pain
  • dry mouth
  • changes in appetite
  • abnormal ejaculation
  • impotence
  • decreased sex drive
  • difficulty having an orgasm
  • dry mouth, and
  • weight loss.

Tell your doctor if you have serious side effects of Zoloft including:

  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
  • agitation, hallucinations, fever, overactive reflexes, tremors;
  • nausea, vomiting, loss of appetite, feeling unsteady, loss of coordination;
  • trouble concentrating, memory problems, weakness, fainting, seizure, shallow breathing, or breathing that stops.

What Is Zulresso?

Zulresso (vortioxetine) tablets are an antidepressant indicated for the treatment of major depressive disorder (MDD).

What Is Zoloft?

Zoloft is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD). Zoloft belongs to a class of medicines known as SSRIs.

Zoloft is also used to treat or manage:

  • Major Depressive Disorder (MDD)
  • Obsessive Compulsive Disorder (OCD)
  • Panic Disorder
  • Posttraumatic Stress Disorder (PTSD)
  • Social Anxiety Disorder
  • Premenstrual Dysphoric Disorder (PMDD)

It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it. You should discuss all treatment choices with your healthcare provider.

Zoloft is safe and effective in treating children with OCD age 6 to 17 years.

It is not known if Zoloft is safe and effective for use in children under 6 years of age with OCD or children with other behavior health conditions.

Talk to your healthcare provider if you do not think that your condition is getting better with Zoloft treatment.

SLIDESHOW

Learn to Spot Depression: Symptoms, Warning Signs, Medication See Slideshow

What Drugs Interact With Zulresso?

Zulresso may interact with monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, buspirone, tramadol, tryptophan products, NSAIDs, aspirin, warfarin, bupropion, fluoxetine, paroxetine, quinidine, rifampicin, carbamazepine, and phenytoin. Tell your doctor all medications and supplements you use.

What Drugs Interact With Zoloft?

Do Not take Zoloft if you:

  • take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid.
  • have taken an MAOI within 2 weeks of stopping Zoloft unless directed to do so by your healthcare provider.
  • have stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider.
  • take any other medicines that contain sertraline (such as sertraline HCl or sertraline hydrochloride).
  • take the antipsychotic medicine pimozide (Orap®) because this can cause serious heart problems.
  • are allergic to sertraline or any of the ingredients in Zoloft. See the end of this Medication Guide for a complete list of ingredients in Zoloft.
  • take Antabuse® (disulfiram) (if you are taking the liquid form of Zoloft) due to the alcohol content.

People who take Zoloft close in time to an MAOI may have serious or even life-threatening side effects. Get medical help right away if you have any of these symptoms:

  • high fever
  • uncontrolled muscle spasms
  • stiff muscles
  • rapid changes in heart rate or blood
  • confusion
  • loss of consciousness (pass pressure out)

How Should Zulresso Be Taken?

The recommended starting dose of Zulresso is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated.

How Should Zoloft Be Taken?

  • Take Zoloft exactly as prescribed. Your healthcare provider may need to change the dose of Zoloft until it is the right dose for you.
  • Zoloft Tablets may be taken with or without food.
  • Zoloft Oral Solution may look cloudy or hazy after mixing, this is normal.
  • Zoloft Oral Solution must be diluted before use:
    • Do not mix Zoloft until you are ready to take it.
    • When diluting Zoloft Oral Solution, use only water, ginger ale, lemon/lime soda, lemonade, or orange juice.
    • The oral dropper contains latex. If you are sensitive or allergic to latex, ask your healthcare provider or pharmacist about the best way to measure your medicine.
  • If you miss a dose of Zoloft, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time.Do not take two doses of Zoloft at the same time.

If you take too much Zoloft, call your healthcare provider or poison control center right away, or go to the nearest hospital emergency room right away.

QUESTION

Depression is a(n) __________ . See Answer
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References

Sage Therapeutics. Zulresso Drug Information.

www.zulresso.com

Pfizer. Zoloft Product Information.

https://www.zoloft.com/

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