Are Zyban and Chantix the Same Thing?
Zyban (bupropion) and Chantix (varenicline) are used for smoking cessation.
The Wellbutrin brand of bupropion is used to treat depression.
Zyban is an antidepressant and Chantix is a partial agonist selective for a4ß2 nicotinic acetylcholine receptor subtypes.
Side effects of Zyban and Chantix that are similar include dry mouth, sleep problems (insomnia), headache, nausea (may persist for several months with Chantix), stomach pain, and constipation.
Side effects of Zyban that are different from Chantix include agitation, dizziness, tremor, weight loss or gain, changes in appetite, ringing in your ears, loss of interest in sex, sore throat, muscle pain, itching or skin rash, increased sweating, and increased urination.
Seizures may also occur, especially at higher doses of Zyban.
Side effects of Chantix that are different from Zyban include indigestion, gas, vomiting, weakness, tiredness, unusual dreams, and unpleasant taste in your mouth.
Both Zyban and Chantix may interact with alcohol, theophylline, blood thinners, and insulin.
Zyban may also interact with heart or blood pressure medications, HIV/AIDS medications, seizure medications, other antidepressants, medicines to treat psychiatric disorders, antibiotics, antihistamines that make you sleepy, asthma medications or bronchodilators, birth control pills or hormone replacement estrogens, bladder or urinary medications, diet pills, stimulants, ADHD medications, oral diabetes medications, medicines for nausea/vomiting or motion sickness, medications to treat or prevent malaria; medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor; medicines used to prevent organ transplant rejection, narcotics, numbing medicines, steroids, street drugs, or ulcer or irritable bowel medications.
Chantix may also interact with other medicines to quit smoking.
Chantix is not addictive and is not a controlled substance; however, some patients may experience withdrawal symptoms such as irritability and sleep disturbance if Chantix is abruptly discontinued.
What Are Possible Side Effects of Zyban?
Common side effects of Zyban include:
- dry mouth,
- stomach pain,
- weight loss or gain,
- changes in appetite,
- ringing in your ears,
- loss of interest in sex,
- sore throat,
- muscle pain,
- itching or skin rash,
- increase sweating, or
- increased urination.
Seizures may also occur, especially at higher doses of Zyban. Tell your doctor if you have unlikely but serious side effects of Zyban including:
- chest pain,
- fast or pounding heartbeat,
- irregular heartbeat,
- mental/mood changes (e.g., anxiety, agitation, confusion, memory loss),
- muscle aches,
- ringing in the ears,
- severe headache,
- uncontrolled movements (tremor), or
- unusual weight loss or gain.
What Are Possible Side Effects of Chantix?
Common side effects of Chantix include:
- nausea (may persist for several months),
- stomach pain,
- unusual dreams,
- sleep problems (insomnia),
- headache, dry mouth, or
- unpleasant taste in your mouth.
Chantix is not addictive and is not a controlled substance; however, some patients may experience irritability and sleep disturbance if Chantix is abruptly discontinued. Patients may experience psychiatric symptoms such as behavioral changes, agitation, depressed mood, and suicidal behavior while using Chantix. Tell your doctor if you have serious side effects of Chantix including
- burning feeling in feet/toes, or
- unusual pain in the legs when walking.
What Is Zyban?
Zyban (bupropion) is an antidepressant in the aminoketone drug class used for smoking cessation.
What Is Chantix?
Chantix (varenicline) is a partial agonist selective for a4ß2 nicotinic acetylcholine receptor subtypes used for cessation of smoking.
What Drugs Interact With Zyban?
Zyban may interact with medication used to prevent blood clots, heart or blood pressure medications, HIV or AIDS medication, seizure medications, other antidepressants, medicines to treat psychiatric disorders, antibiotics, antihistamines that make you sleepy, asthma medications or bronchodilators, birth control pills or hormone replacement estrogens, bladder or urinary medications, diet pills, stimulants, ADHD medications, insulin or oral diabetes medications, medicines for nausea/vomiting or motion sickness, medications to treat or prevent malaria; medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor; medicines used to prevent organ transplant rejection, narcotics, numbing medicines, steroids, street drugs, theophylline, or ulcer or irritable bowel medications. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Zyban; it is unknown if it will harm a fetus. Zyban can pass into breast milk and may harm a nursing baby. Breastfeeding while using Zyban is not recommended.
What Drugs Interact With Chantix?
Chantix may interact with other drugs.
How Should Zyban Be Taken?
The usual dose of Zyban is 150 to 450 mg daily.
How Should Chantix Be Taken?
The recommended dose of Chantix is 0.5 mg daily for 3 days followed by 0.5 mg twice daily for 4 days, then 1 mg twice daily for the remainder of the treatment period. Duration of therapy is 12 weeks. If treatment is successful, continue for an additional 12 weeks in order increase the chance of long-term abstinence.
Smoking Cessation Resources
Health Solutions From Our Sponsors
All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).
Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.
Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.
The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.
As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.
Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.
If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.
You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.
GSK. Zyban Product Information.
Pfizer. Chantix Product Monograph.