Zyloprim

Last updated on RxList: 10/14/2020
Zyloprim Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Zyloprim?

Zyloprim (allopurinol) is a xanthine oxidase inhibitor that reduces the production of uric acid. Zyloprim is used to prevent gout attacks by reducing uric acid production; high levels of uric acid may cause gout or kidney stones. Zyloprim is available as a generic termed allopurinol.

What Are Side Effects of Zyloprim?

Side effects of Zyloprim include:

Tell your doctor if you experience rare but very serious side effects of Zyloprim including:

  • numbness or tingling of arms or legs,
  • easy bleeding or bruising,
  • signs of infection (e.g., fever, persistent sore throat),
  • unusual tiredness,
  • painful or bloody urination,
  • change in the amount of urine,
  • yellowing eyes or skin,
  • severe stomach or abdominal pain,
  • persistent nausea or vomiting,
  • dark urine,
  • unusual weight loss,
  • eye pain, or
  • vision changes.

Dosage for Zyloprim?

Zyloprim is available in 100 and 300 mg strength tablets. The usual doses start at 200 - 300 mg per day; dosage for children with hyperuricemia under 6 years old is 150 mg per day. Zyloprim is usually recommended to be taken after a meal.

What Drugs, Substances, or Supplements Interact with Zyloprim?

Zyloprim may interact with azathioprine, chlorpropamide, cyclosporine, mercaptopurine, antibiotics, blood thinners, or diuretics (water pills). Tell your doctor all medications and supplements you use.

Zyloprim During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant while using Zyloprim; it is unknown if Zyloprim will harm a fetus. Zyloprim passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Zyloprim Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Gout Attack Symptoms, Causes, Treatment, and Diet See Slideshow
Zyloprim Consumer Information

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Stop using this medicine and get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Stop using allopurinol and call your doctor at once if you have:

  • any skin rash, no matter how mild;
  • painful urination, blood in the urine;
  • little or no urination;
  • easy bruising, unusual bleeding;
  • numbness, tingling, burning pain;
  • worsening gout symptoms; or
  • liver problems--loss of appetite, weight loss, stomach pain (upper right side), itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • an increase in gout attacks when you first starting taking allopurinol oral;
  • rash;
  • drowsiness;
  • fever, chills;
  • abnormal liver function tests;
  • nausea, diarrhea; or
  • joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Zyloprim (Allopurinol)

QUESTION

Gout is a form of arthritis. See Answer
Zyloprim Professional Information

SIDE EFFECTS

Data upon which the following estimates of incidence of adverse reactions are made are derived from experiences reported in the literature, unpublished clinical trials and voluntary reports since marketing of ZYLOPRIM (allopurinol) began. Past experience suggested that the most frequent event following the initiation of allopurinol treatment was an increase in acute attacks of gout (average 6% in early studies). An analysis of current usage suggests that the incidence of acute gouty attacks has diminished to less than 1%. The explanation for this decrease has not been determined but may be due in part to initiating therapy more gradually (see PRECAUTIONS and DOSAGE AND ADMINISTRATION).

The most frequent adverse reaction to ZYLOPRIM (allopurinol) is skin rash. Skin reactions can be severe and sometimes fatal. Therefore, treatment with ZYLOPRIM (allopurinol) should be discontinued immediately if a rash develops (see WARNINGS). Some patients with the most severe reaction also had fever, chills, arthralgias, cholestatic jaundice, eosinophilia and mild leukocytosis or leukopenia. Among 55 patients with gout treated with ZYLO-PRIM for 3 to 34 months (average greater than 1 year) and followed prospectively, Rundles observed that 3% of patients developed a type of drug reaction which was predominantly a pru-ritic maculopapular skin eruption, sometimes scaly or exfolia-tive. However, with current usage, skin reactions have been observed less frequently than 1%. The explanation for this decrease is not obvious. The incidence of skin rash may be increased in the presence of renal insufficiency. The frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with ZYLOPRIM (allopurinol) has been reported to be increased (see PRECAUTIONS).

Most Common Reactions* Probably Causally Related:

Gastrointestinal: Diarrhea, nausea, alkaline phosphatase increase, SGOT/SGPT increase.

Metabolic and Nutritional: Acute attacks of gout.

Skin and Appendages: Rash, maculopapular rash.

*Early clinical studies and incidence rates from early clinical experience with ZYLOPRIM (allopurinol) suggested that these adverse reactions were found to occur at a rate of greater than 1%. The most frequent event observed was acute attacks of gout following the initiation of therapy. Analyses of current usage suggest that the incidence of these adverse reactions is now less than 1%. The explanation for this decrease has not been determined, but it may be due to following recommended usage (see ADVERSE REACTIONS introduction, INDICATIONS AND USAGE, PRECAUTIONS, and DOSAGE AND ADMINISTRATION).

Incidence Less Than 1% Probably Causally Related:

Body As a Whole: Ecchymosis, fever, headache.

Cardiovascular: Necrotizing angiitis, vasculitis.

Gastrointestinal: Hepatic necrosis, granulomatous hepatitis, hepatomegaly, hyperbilirubinemia, cholestatic jaundice, vomiting, intermittent abdominal pain, gastritis, dyspepsia.

Hemic and Lymphatic: Thrombocytopenia, eosinophilia, leukocytosis, leukopenia.

Musculoskeletal: Myopathy, arthralgias.

Nervous: Peripheral neuropathy, neuritis, paresthesia, somnolence.

Respiratory: Epistaxis.

Skin and Appendages: Erythema multiforme exudativum (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), hypersensitivity vasculitis, purpura, vesicular bullous dermatitis, exfoliative dermatitis, eczematoid dermatitis, pruritus, urticaria, alopecia, onycholysis, lichen planus.

Special Senses: Taste loss/perversion.

Urogenital: Renal failure, uremia (see PRECAUTIONS).

Incidence Less Than 1% Causal Relationship Unknown:

Body As a Whole: Malaise.

Cardiovascular: Pericarditis, peripheral vascular disease, thrombophlebitis, bradycardia, vasodilation.

Endocrine: Infertility (male), hypercalcemia, gynecomastia (male).

Gastrointestinal: Hemorrhagic pancreatitis, gastrointestinal bleeding, stomatitis, salivary gland swelling, hyperlipidemia, tongue edema, anorexia.

Hemic and Lymphatic: Aplastic anemia, agranulocytosis, eosinophilic fibrohistiocytic lesion of bone marrow, pancyto-penia, prothrombin decrease, anemia, hemolytic anemia, reticu-locytosis, lymphadenopathy, lymphocytosis.

Musculoskeletal: Myalgia.

Nervous: Optic neuritis, confusion, dizziness, vertigo, foot drop, decrease in libido, depression, amnesia, tinnitus, asthenia, insomnia.

Respiratory: Bronchospasm, asthma, pharyngitis, rhinitis.

Skin and Appendages: Furunculosis, facial edema, sweating, skin edema.

Special Senses: Cataracts, macular retinitis, iritis, conjunctivitis, amblyopia.

Urogenital: Nephritis, impotence, primary hematuria, albu-minuria.

Read the entire FDA prescribing information for Zyloprim (Allopurinol)

© Zyloprim Patient Information is supplied by Cerner Multum, Inc. and Zyloprim Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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