Last updated on RxList: 7/12/2019
Zymar Side Effects Center

Last reviewed on RxList 7/12/2019

Zymar (gatifloxacin ophthalmic solution) is a fluoroquinolone antibiotic used to treat eye infections caused by bacteria. Zymar is available in generic form. Common side effects of Zymar include:

  • blurred vision,
  • watery eyes,
  • headache,
  • eye itching/burning/irritation/pain/ dryness/redness,
  • watery eyes,
  • puffy eyelids,
  • headache, or
  • bad or unpleasant taste in your mouth after using the drops.

Tell your doctor if you have unlikely but serious side effects of Zymar including:

  • persistent eye redness, or
  • swelling of the eye or eyelid.

The recommended dosage regimen of Zymar for the treatment of bacterial conjunctivitis is: Days 1 and 2: Instill one drop every two hours in the affected eye(s) while awake, up to 8 times daily; Days 3 through 7: Instill one drop up to four times daily while awake. It is not likely other drugs you take orally or inject will have an effect on Zymar used in the eyes. But many drugs can interact with each other. Tell your doctor all medications you use, especially: theophylline, blood thinners, or cyclosporine used in the eyes or taken by mouth. Zymar should be used only when prescribed during pregnancy. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Our Zymar (gatifloxacin ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Zymar Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; slow heart rate, weak pulse, fainting; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • eye swelling, severe discomfort, crusting or drainage (may be signs of a new infection); or
  • any new or worsening eye problems.

Common side effects may include:

  • mild itching, burning, redness, or irritation;
  • watery eyes; or
  • puffy eyelids.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Zymar (Gatifloxacin Ophthalmic Solution)


Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow
Zymar Professional Information


The following serious adverse reactions are described elsewhere in the labeling:

Clinical Studies Experience

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.

In clinical studies with ZYMAR®, the most frequently reported adverse reactions in the overall study population were: conjunctival irritation, increased lacrimation, keratitis, and papillary conjunctivitis. These reactions occurred in approximately 5-10% of patients. Other reported reactions occurring in 1-4% of patients were chemosis, conjunctival hemorrhage, dry eye, eye discharge, eye pain, eyelid edema, headache, red eye, reduced visual acuity and taste disturbance.

An additional adverse reaction reported with gatifloxacin ophthalmic solution in other clinical studies includes worsening of the conjunctivitis.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of gatifloxacin ophthalmic solution 0.3%. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These reactions include: anaphylactic reactions and angioedema (including pharyngeal, oral or facial edema), blepharitis, dyspnea, eye pruritus, eye swelling (including corneal and conjunctival edema), hypersensitivity, nausea, pruritus (including pruritus generalized), rash, urticaria, vision blurred.

Read the entire FDA prescribing information for Zymar (Gatifloxacin Ophthalmic Solution)

© Zymar Patient Information is supplied by Cerner Multum, Inc. and Zymar Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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